环境颗粒物水平与高血压之间的关联：韩国基因组与流行病学研究结果
Association between ambient particulate matter levels and hypertension: results from the Korean Genome and Epidemiology Study.
作者信息
Na Sewhan, Park Jong-Tae, Kim Seungbeom, Han Jinwoo, Jung Saemi, Kwak Kyeongmin
机构信息
Department of Occupational and Environmental Medicine, Korea University Ansan Hospital, Ansan, Korea.
Department of Environmental Health Sciences, Seoul National University Graduate School of Public Health, Seoul, Korea.
出版信息
Ann Occup Environ Med. 2023 Dec 4;35:e51. doi: 10.35371/aoem.2023.35.e51. eCollection 2023.
BACKGROUND
Recently, there has been increasing worldwide concern about outdoor air pollution, especially particulate matter (PM), which has been extensively researched for its harmful effects on the respiratory system. However, sufficient research on its effects on cardiovascular diseases, such as hypertension, remains lacking. In this study, we examine the associations between PM levels and hypertension and hypothesize that higher PM concentrations are associated with elevated blood pressure.
METHODS
A total of 133,935 adults aged ≥ 40 years who participated in the Korean Genome and Epidemiology Study were analyzed. Multiple linear regression analyses were conducted to investigate the short- (1-14 days), medium- (1 and 3 months), and long-term (1 and 2 years) impacts of PM on blood pressure. Logistic regression analyses were conducted to evaluate the medium- and long-term effects of PM on blood pressure elevation after adjusting for sex, age, body mass index, health-related lifestyle behaviors, and geographic areas.
RESULTS
Using multiple linear regression analyses, both crude and adjusted models generated positive estimates, indicating an association with increased blood pressure, with all results being statistically significant, with the exception of PM levels over the long-term period (1 and 2 years) in non-hypertensive participants. In the logistic regression analyses on non-hypertensive participants, moderate PM (particulate matter with diameters < 10 μm) and PM (particulate matter with diameters < 2.5 μm) levels over the long-term period and all high PM and PM levels were statistically significant after adjusting for various covariates. Notably, high PM levels of the 1 year exhibited the highest odds ratio of 1.23 (95% confidence interval: 1.19-1.28) after adjustment.
CONCLUSIONS
These findings suggest that both short- and long-term exposure to PM is associated with blood pressure elevation.
背景
最近，全球对室外空气污染的关注日益增加，尤其是颗粒物（PM），其对呼吸系统的有害影响已得到广泛研究。然而，关于其对心血管疾病（如高血压）影响的充分研究仍然缺乏。在本研究中，我们检验了PM水平与高血压之间的关联，并假设较高的PM浓度与血压升高有关。
方法
对133,935名年龄≥40岁且参与韩国基因组与流行病学研究的成年人进行了分析。进行了多元线性回归分析，以研究PM对血压的短期（1 - 14天）、中期（1和3个月）和长期（1和2年）影响。进行了逻辑回归分析，以评估在调整性别、年龄、体重指数、与健康相关的生活方式行为和地理区域后，PM对血压升高的中期和长期影响。
结果
使用多元线性回归分析，粗模型和调整模型均产生了正向估计值，表明与血压升高有关，除了非高血压参与者的长期（1和2年）PM水平外，所有结果均具有统计学意义。在对非高血压参与者的逻辑回归分析中，在调整各种协变量后，长期的中度PM（直径<10μm的颗粒物）和PM（直径<2.5μm的颗粒物）水平以及所有高PM和PM水平均具有统计学意义。值得注意的是，在调整后，1年的高PM水平显示出最高的优势比1.23（95%置信区间：1.19 - 1.28）。
结论
这些发现表明，短期和长期暴露于PM均与血压升高有关。
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