Popa Alina Delia, Niță Otilia, Caba Lavinia, Gherasim Andreea, Graur Mariana, Mihalache Laura, Arhire Lidia Iuliana
Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.
Faculty of Medicine and Biological Sciences, University "Ștefan cel Mare" of Suceava, 720229 Suceava, Romania.
Metabolites. 2023 Dec 20;14(1):4. doi: 10.3390/metabo14010004.
Obesity affects more than one billion people worldwide and often leads to cardiometabolic chronic comorbidities. It induces senescence-related alterations in adipose tissue, and senescence is closely linked to obesity. Fully elucidating the pathways through which vitamin D exerts anti-inflammatory effects may improve our understanding of local adipose tissue inflammation and the pathogenesis of metabolic disorders. In this narrative review, we compiled and analyzed the literature from diverse academic sources, focusing on recent developments to provide a comprehensive overview of the effect of vitamin D on inflammation associated with obesity and senescence. The article reveals that the activation of the NF-κB (nuclear factor kappa B subunit 1) and NLRP3 inflammasome (nucleotide-binding domain, leucine-rich-containing, pyrin domain-containing-3) pathways through the toll-like receptors, which increases oxidative stress and cytokine release, is a common mechanism underlying inflammation associated with obesity and senescence, and it discusses the potential beneficial effect of vitamin D in alleviating the development of subclinical inflammation. Investigating the main target cells and pathways of vitamin D action in adipose tissue could help uncover complex mechanisms of obesity and cellular senescence. This review summarizes significant findings related to opportunities for improving metabolic health.
肥胖影响着全球超过10亿人，常常导致心脏代谢方面的慢性合并症。它会在脂肪组织中引发与衰老相关的改变，而衰老与肥胖密切相关。全面阐明维生素D发挥抗炎作用的途径，可能会增进我们对局部脂肪组织炎症以及代谢紊乱发病机制的理解。在这篇叙述性综述中，我们收集并分析了来自不同学术来源的文献，聚焦于近期进展，以全面概述维生素D对与肥胖和衰老相关炎症的影响。文章揭示，通过Toll样受体激活NF-κB（核因子κB亚基1）和NLRP3炎性小体（含核苷酸结合结构域、富含亮氨酸重复序列和吡啉结构域的蛋白3）途径，会增加氧化应激和细胞因子释放，这是与肥胖和衰老相关炎症的共同潜在机制，并且探讨了维生素D在减轻亚临床炎症发展方面的潜在有益作用。研究维生素D在脂肪组织中的主要靶细胞和作用途径，有助于揭示肥胖和细胞衰老的复杂机制。本综述总结了与改善代谢健康机会相关的重要发现。
