Faryabi Ali, Salari Mohammad Amin, Dalvand Alaleh, Akbarniakhaky Hassan, Mohammadi Ghazal, Aazami Hossein, Razi Farideh, Dehghanbanadaki Hojat
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.
J Diabetes Metab Disord. 2025 Mar 10;24(1):78. doi: 10.1007/s40200-025-01594-9. eCollection 2025 Jun.
This comprehensive study examines the multifaceted relationship between vitamin D and cancer, synthesizing key scientific advancements and global research trends to guide future investigations and address critical gaps in the field.
Publications on vitamin D and cancer were retrieved from Scopus up to November 2024. English-language original and review articles were analyzed using Excel, VOSviewer, and Scimago Graphica, focusing on publication trends, citation impacts, and research themes.
A total of 11,442 publications (80.01% original articles, 19.98% reviews; 51.24% open access) were analyzed. The United States of America led in publications (38.3%) and citations (56.2%), followed by China (7.7%) and the United Kingdom (7.2%) in output, and the United Kingdom (10.6%) and Germany (6.4%) in citations. Countries with the highest citations per document were Belgium (103.4), Slovenia (87.9), and Puerto Rico (76.6). The most frequently studied cancers in relation to vitamin D were breast, colorectal, prostate, skin, lung, ovarian, pancreatic, gastric, hepatocellular, thyroid, leukemia, multiple myeloma, bladder, lymphoma, osteosarcoma, cervical, endometrial, and glioblastoma, respectively. Cluster analysis revealed key patterns related to vitamin D: Calcitriol's chemopreventive role in breast, prostate, and colorectal cancers, dietary vitamin D for its involvement in ovarian cancer, vitamin D for regulation of cancer-related hypercalcemia, vitamin D deficiency links to inflammation-obesity-cancer risk, VDR polymorphisms affecting outcomes in lung and colorectal cancers, and vitamin D's photoprotective effects on skin malignancies, and vitamin D in ulcerative colitis-related cancer. The most cited articles emphasized optimal vitamin D levels and cancer prevention.
This study highlights the extensive research on vitamin D and its complex links to cancer, emphasizing future prospects with a focus on precision medicine approaches, including targeted supplementation and genomic analyses, to better address individual variability in cancer prevention and treatment.
本全面研究探讨了维生素D与癌症之间的多方面关系，综合关键科学进展和全球研究趋势，以指导未来研究并填补该领域的关键空白。
截至2024年11月，从Scopus数据库中检索关于维生素D与癌症的出版物。使用Excel、VOSviewer和Scimago Graphica对英文原创文章和综述进行分析，重点关注出版趋势、引文影响和研究主题。
共分析了11442篇出版物（80.01%为原创文章，19.98%为综述；51.24%为开放获取）。美国在出版物数量（38.3%）和引文数量（56.2%）方面领先，其次是中国（产出占7.7%）和英国（产出占7.2%），在引文方面，英国（10.6%）和德国（6.4%）领先。每篇文献引用次数最高的国家是比利时（103.4）、斯洛文尼亚（87.9）和波多黎各（76.6）。与维生素D相关研究最多的癌症分别是乳腺癌、结直肠癌、前列腺癌、皮肤癌、肺癌、卵巢癌、胰腺癌、胃癌、肝细胞癌、甲状腺癌、白血病、多发性骨髓瘤、膀胱癌、淋巴瘤、骨肉瘤、宫颈癌、子宫内膜癌和胶质母细胞瘤。聚类分析揭示了与维生素D相关的关键模式：骨化三醇在乳腺癌、前列腺癌和结直肠癌中的化学预防作用，饮食中的维生素D与卵巢癌的关系，维生素D对癌症相关高钙血症的调节作用，维生素D缺乏与炎症 - 肥胖 - 癌症风险的联系，维生素D受体多态性对肺癌和结直肠癌预后的影响，维生素D对皮肤恶性肿瘤的光保护作用，以及维生素D在溃疡性结肠炎相关癌症中的作用。被引用次数最多的文章强调了最佳维生素D水平与癌症预防。
本研究突出了对维生素D及其与癌症复杂联系的广泛研究，强调了未来的前景，重点是精准医学方法，包括靶向补充和基因组分析，以更好地应对癌症预防和治疗中的个体差异。
