Jiang Yibei, Wang Zhou, Cao Ke, Xia Lu, Wei Dongqing, Zhang Yi
Department of Inorganic Materials, School of Minerals Processing and Bioengineering, Central South University, Changsha 410083, China.
Department of Oncology, The Third Xiangya Hospital of Central South University, Changsha 410078, China.
J Funct Biomater. 2023 Dec 19;15(1):3. doi: 10.3390/jfb15010003.
The montmorillonite-sodium alginate (MMT-SA) colon-targeting microcapsules have been designed as a WGX-50 encapsulation and controlled release vehicle used in oral administration. The MMT-SA microcapsule was formed from a cross-linking reaction, and the stable micropore in the microcapsule changed with a different MMT-SA mixed mass ratio. The MMT-SA microcapsule has a reinforced micropore structure and an enhanced swell-dissolution in SIF and SCF with alkaline environment, which is attributed to the incorporated MMT. The MMT-SA microcapsule exhibited a high WGX-50 encapsulation rate up to 98.81 ± 0.31% and an obvious WGX-50 controlled release in the simulated digestive fluid in vitro. The WGX-50 loaded with MMT-SA microcapsule showed a weak minimizing drug loss in SGF (Simulated Gastric Fluid) with an acidic environment, while it showed a strong maximizing drug release in SIF (Simulated Intestinal Fluid) and SCF (Simulated Colonic Fluid) with an alkaline environment. These features make the MMT-SA microcapsule a nominated vehicle for colon disease treatment used in oral administration.
蒙脱石-海藻酸钠（MMT-SA）结肠靶向微胶囊被设计为一种用于口服给药的WGX-50包封和控释载体。MMT-SA微胶囊通过交联反应形成，微胶囊中稳定的微孔会随MMT-SA混合质量比的不同而变化。MMT-SA微胶囊具有增强的微孔结构，在具有碱性环境的模拟肠液（SIF）和模拟结肠液（SCF）中具有增强的溶胀-溶解性能，这归因于所掺入的蒙脱石。MMT-SA微胶囊表现出高达98.81±0.31%的高WGX-50包封率，并且在体外模拟消化液中对WGX-50具有明显的控释作用。负载WGX-50的MMT-SA微胶囊在具有酸性环境的模拟胃液（SGF）中显示出较弱的药物损失最小化，而在具有碱性环境的模拟肠液（SIF）和模拟结肠液（SCF）中显示出较强的药物释放最大化。这些特性使MMT-SA微胶囊成为用于口服给药治疗结肠疾病的指定载体。
