Mondino B J, Caster A I, Dethlefs B
Arch Ophthalmol. 1987 Mar;105(3):409-12. doi: 10.1001/archopht.1987.01060030129042.
Rabbits immunized with cell wall antigens of Staphylococcus aureus developed blepharitis after topical challenge with viable S aureus. The lids of these rabbits were thickened and erythematous. Crusting was found around the lashes, and the lids developed loss of lashes and hair. Histopathologic examination of lids from rabbits with blepharitis showed a dense leukocytic infiltrate and dilated blood vessels beneath an intact epidermis and palpebral conjunctival epithelium. The infiltrate contained neutrophils as well as mononuclear cells, including macrophages, plasma cells, and lymphocytes. The meibomian glands appeared normal. Gram's staining of lid sections did not show gram-positive cocci. The results of this study suggest that hypersensitivity to the S aureus cell wall, and particularly the ribitol teichoic acid that it contains, plays a role in the pathogenesis of staphylococcal blepharitis.
用金黄色葡萄球菌细胞壁抗原免疫的兔子，在用活的金黄色葡萄球菌进行局部攻击后发生了睑缘炎。这些兔子的眼睑增厚且发红。在睫毛周围发现结痂，眼睑出现睫毛和毛发脱落。对患有睑缘炎的兔子的眼睑进行组织病理学检查，结果显示在完整的表皮和睑结膜上皮下方有密集的白细胞浸润和扩张的血管。浸润物中含有中性粒细胞以及单核细胞，包括巨噬细胞、浆细胞和淋巴细胞。睑板腺看起来正常。眼睑切片的革兰氏染色未显示革兰氏阳性球菌。这项研究的结果表明，对金黄色葡萄球菌细胞壁，特别是其中所含的核糖醇磷壁酸过敏，在葡萄球菌性睑缘炎的发病机制中起作用。
