Ge Zhenyu, Wang Kai, Zhang Zhaomei, Zhang Xiaoqian, Sun Peng, Chen Ning, Tan Yang, Shen Tingting, Dai Hongsheng, Li Wenwen
Department Gastroenterology, Affiliated Hospital of Weifang Medical University, Weifang City, Shandong Province, China.
Department Vascular intervention, Affiliated Hospital of Weifang Medical University, Weifang City, Shandong Province, China.
Medicine (Baltimore). 2024 Jan 26;103(4):e36886. doi: 10.1097/MD.0000000000036886.
Hepatic artery-portal vein malformation is rarely encountered in clinical practice. Here, we reported a case of liver cirrhosis combined with hepatic artery-portal vein malformation with refractory ascites as the main symptom. And it was successfully treated by us. The present case demonstrates the role of hepatic artery-portal vein malformation in cirrhotic ascites and the importance of early diagnosis and interventional treatment. This article may provides some experience for the treatment of such patients.
The patient was a 72-year-old woman with a 40-year history of Hepatitis B virus surface antigen positivity who sought medical advice with a chief complaint of abdominal distension for 1 week.
Enhanced abdominal computed tomography imaging of this patient revealed liver cirrhosis, splenomegaly, esophageal and gastric varices, massive ascites, and a low-density area in the S4 segment of the liver with an ambiguous boundary. Widening of the left branch of the portal vein was evident, and the portal vein was highlighted in the arterial phase and the venous phase. Digital subtraction angiography revealed substantial thickening of the left hepatic artery, and the administered contrast agent drained through the malformed vascular mass to the thickened left portal vein. Liver cirrhosis combined with hepatic artery-portal vein malformation were diagnosed. And we considered that the artery-portal vein malformation in this patient might be caused by cirrhosis.
The patient was applied diuretics, entecavir and transcatheter embolization.
The patient ascites did not resolve significantly when treated with diuretics alone. After the transcatheter embolization, the patient ascites relieved remarkably.
The patient underwent transcatheter embolization for hepatic artery-portal vein malformation, after which her ascites resolved with good short-term curative efficacy. So, the patients who suffered from liver cirrhosis combined with hepatic artery-portal vein malformation and refractory ascites, should be active on transcatheter embolization.
肝动脉 - 门静脉畸形在临床实践中很少见。在此,我们报告一例以难治性腹水为主要症状的肝硬化合并肝动脉 - 门静脉畸形病例,并成功对其进行了治疗。本病例展示了肝动脉 - 门静脉畸形在肝硬化腹水中的作用以及早期诊断和介入治疗的重要性。本文可为这类患者的治疗提供一些经验。
患者为一名72岁女性,有40年乙肝病毒表面抗原阳性病史,因腹胀1周为主诉前来就医。
该患者的腹部增强计算机断层扫描成像显示肝硬化、脾肿大、食管和胃静脉曲张、大量腹水,以及肝脏S4段边界不清的低密度区。门静脉左支明显增宽,在动脉期和静脉期门静脉均显影。数字减影血管造影显示肝左动脉明显增粗,注入的造影剂通过畸形血管团引流至增粗的门静脉左支。诊断为肝硬化合并肝动脉 - 门静脉畸形。我们认为该患者的动脉 - 门静脉畸形可能由肝硬化引起。
对患者应用了利尿剂、恩替卡韦及经导管栓塞术。
单独使用利尿剂治疗时患者腹水未明显消退。经导管栓塞术后,患者腹水明显缓解。
该患者因肝动脉 - 门静脉畸形接受了经导管栓塞术,术后腹水消退,短期疗效良好。因此,对于患有肝硬化合并肝动脉 - 门静脉畸形及难治性腹水的患者,应积极进行经导管栓塞术。