Van Niekerk J L, Hendriks T, De Boer H H
Atherosclerosis. 1987 Feb;63(2-3):225-30. doi: 10.1016/0021-9150(87)90124-9.
At age of 40 weeks, 9 WHHL rabbits were necropsied as a baseline control group for evaluating aortic and coronary atherosclerosis. An additional 18 WHHL rabbits of the same age underwent either a partial ileal bypass (PIB) or a sham operation. Serum cholesterol concentrations were significantly lower in PIB rabbits than in sham-operated rabbits, mean postsurgical values being 7.9 +/- 2.3 mmol/l and 13.2 +/- 2.4 mmol/l, respectively. This effect was mainly due to a lower LDL-cholesterol concentration. Serum triglycerides remained unaffected. Thirty weeks after surgery the PIB and sham rabbits were necropsied and atherosclerosis was evaluated. Progression of atherosclerotic plaque size in the sham group was most prominent in the aortic arch. PIB largely prevented this progression. The frequency of plaque complications in the aortic arch also increased in the sham groups. Here, no significant improvement was found in the PIB group. Extensive examination of the heart showed some affected coronary arteries in every 40-week-old WHHL rabbit. Progression of coronary atherosclerosis during the postsurgical period was small in both sham and PIB groups. However, while PIB did not affect the plaque size, it significantly reduced the number of coronary arteries affected.
在40周龄时，对9只WHHL兔进行尸检，作为评估主动脉和冠状动脉粥样硬化的基线对照组。另外18只同龄的WHHL兔接受了部分回肠旁路术（PIB）或假手术。PIB兔的血清胆固醇浓度显著低于假手术兔，术后平均数值分别为7.9±2.3毫摩尔/升和13.2±2.4毫摩尔/升。这种效应主要是由于较低的低密度脂蛋白胆固醇浓度。血清甘油三酯未受影响。手术后30周，对PIB兔和假手术兔进行尸检并评估动脉粥样硬化情况。假手术组动脉粥样硬化斑块大小的进展在主动脉弓最为显著。PIB在很大程度上阻止了这种进展。假手术组主动脉弓斑块并发症的发生率也有所增加。在此方面，PIB组未发现明显改善。对心脏进行的广泛检查显示，每只40周龄的WHHL兔都有一些冠状动脉受到影响。在术后期间，假手术组和PIB组冠状动脉粥样硬化的进展都较小。然而，虽然PIB不影响斑块大小，但它显著减少了受影响冠状动脉的数量。
