Vermaak W J, Barnard H C, Potgieter G M, Theron H D
Atherosclerosis. 1987 Feb;63(2-3):235-8. doi: 10.1016/0021-9150(87)90126-2.
The finding of low plasma pyridoxal-5'-phosphate levels in patients suffering from myocardial infarction has been construed as possible evidence for the pathogenetic role that vitamin B6 deficiency may play in causing premature ischaemic heart disease. However, the presence of normal plasma pyridoxal-5'-phosphate levels in patients with angiographic evidence of coronary artery narrowing but with no previous infarctions prompted the investigation of possible short-term alterations in plasma pyridoxal-5'-phosphate levels during the acute phase of myocardial infarction. In the follow-up of 30 patients with acute myocardial infarction, all of them showed a continuous decrease of approximately 45% in plasma pyridoxal-5'-phosphate levels during the acute phase. These levels subsequently returned back to normal before discharge from hospital. A large number of volunteers from an ethnic group known to have a very low incidence of ischaemic heart disease were found to have both significantly lower total cholesterol and plasma pyridoxal-5'-phosphate levels than a Caucasian group in the same geographic area which is known to have a high incidence of ischaemic heart disease. These findings therefore do not support the contention that vitamin B6 deficiency may be a risk index for ischaemic heart disease.
心肌梗死患者血浆磷酸吡哆醛 -5'- 磷酸水平较低这一发现，被视为维生素B6缺乏可能在引发早发性缺血性心脏病中起致病作用的潜在证据。然而，冠状动脉造影显示有狭窄但既往无梗死的患者，其血浆磷酸吡哆醛 -5'- 磷酸水平正常，这促使人们对心肌梗死急性期血浆磷酸吡哆醛 -5'- 磷酸水平可能的短期变化展开研究。在对30例急性心肌梗死患者的随访中，所有患者在急性期血浆磷酸吡哆醛 -5'- 磷酸水平持续下降约45%。这些水平随后在出院前恢复正常。在一个已知缺血性心脏病发病率极低的族群中，大量志愿者被发现其总胆固醇和血浆磷酸吡哆醛 -5'- 磷酸水平均显著低于同一地理区域已知缺血性心脏病发病率高的白种人群体。因此，这些发现并不支持维生素B6缺乏可能是缺血性心脏病风险指标这一论点。
