Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, China.
Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, China.
Prog Biophys Mol Biol. 2024 Mar;187:36-50. doi: 10.1016/j.pbiomolbio.2024.01.003. Epub 2024 Jan 26.
Tissue repair and regeneration is a vital biological process in organisms, which is influenced by various internal mechanisms and microenvironments. Pulsed electromagnetic fields (PEMFs) are becoming a potential medical technology due to its advantages of effectiveness and non-invasiveness. Numerous studies have demonstrated that PEMFs can stimulate stem cell proliferation and differentiation, regulate inflammatory reactions, accelerate wound healing, which is of great significance for tissue regeneration and repair, providing a solid basis for enlarging its clinical application. However, some important issues such as optimal parameter system and potential deep mechanisms remain to be resolved due to PEMFs window effect and biological complexity. Thus, it is of great importance to comprehensively summarizing and analyzing the literature related to the biological effects of PEMFs in tissue regeneration and repair. This review expounded the biological effects of PEMFs on stem cells, inflammation response, wound healing and musculoskeletal disorders in order to improve the application value of PEMFs in medicine. It is believed that with the continuous exploration of biological effects of PEMFs, it will be applied increasingly widely to tissue repair and other diseases.
组织修复和再生是生物体内的一个重要的生物学过程，其受到各种内部机制和微环境的影响。脉冲电磁场（PEMFs）因其有效性和非侵入性的优点，正成为一种有潜力的医学技术。大量研究表明，PEMFs 可以刺激干细胞的增殖和分化，调节炎症反应，加速伤口愈合，这对于组织再生和修复具有重要意义，为扩大其临床应用提供了坚实的基础。然而，由于 PEMFs 的窗口效应和生物复杂性，一些重要的问题，如最佳参数系统和潜在的深层机制，仍有待解决。因此，全面总结和分析与 PEMFs 在组织再生和修复中的生物学效应相关的文献具有重要意义。本综述阐述了 PEMFs 对干细胞、炎症反应、伤口愈合和肌肉骨骼疾病的生物学效应，旨在提高 PEMFs 在医学中的应用价值。相信随着对 PEMFs 生物学效应的不断探索，它将在组织修复等疾病的治疗中得到越来越广泛的应用。
