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505 Parnassus Avenue, M545, Box #0102, San Francisco, CA 94143, USA.
Gastroenterol Clin North Am. 2024 Mar;53(1):109-132. doi: 10.1016/j.gtc.2023.11.005. Epub 2023 Dec 16.
This review discusses the diagnostic challenges of diagnosing and treating precursor lesions of hepatocellular carcinoma (HCC) in both cirrhotic and non-cirrhotic livers. The distinction of high-grade dysplastic nodule (the primary precursor lesion in cirrhotic liver) from early HCC is emphasized based on morphologic, immunohistochemical, and genomic features. The risk factors associated with HCC in hepatocellular adenomas (precursor lesion in non-cirrhotic liver) are delineated, and the risk in different subtypes is discussed with emphasis on terminology, diagnosis, and genomic features.
这篇综述讨论了在肝硬化和非肝硬化肝脏中诊断和治疗肝细胞癌（HCC）前体病变的诊断挑战。强调了根据形态学、免疫组织化学和基因组特征，将高级别异型增生结节（肝硬化肝脏中的主要前体病变）与早期 HCC 区分开来。描述了肝细胞腺瘤（非肝硬化肝脏中的前体病变）中与 HCC 相关的危险因素，并讨论了不同亚型的风险，重点是术语、诊断和基因组特征。
