Zhou Wei, Pawliszyn Janusz
Department of Chemistry, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.
Department of Chemistry, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.
Anal Chim Acta. 2024 Feb 22;1291:342244. doi: 10.1016/j.aca.2024.342244. Epub 2024 Jan 14.
The direct coupling of solid-phase microextraction (SPME) with mass spectrometry (MS) offers rapid analysis with high sensitivity and low matrix effects by benefiting from the integration of sampling, high enrichment, and clean-up functions of SPME. Eliminating chromatographic separation reduces the amount of gas/solvent needed for analysis, while direct desorption in SPME-MS consumes none or few microliters of organic solvents per sample, further enhancing the greenness of the SPME technology. Over the past two decades, the rapid evolution of SPME-MS has given rise to numerous novel technologies that employ diverse ionization techniques and interfaces, several of which have already been commercialized. Drawing from an extensive review published earlier this year and our research experience, we provide perspectives on three aspects of these technologies: interface design and automation, integration with state-of-art MS instrumentation, and anticipated future developments.
固相微萃取（SPME）与质谱（MS）的直接联用，借助SPME的采样、高富集和净化功能的整合，实现了高灵敏度、低基质效应的快速分析。消除色谱分离减少了分析所需的气体/溶剂量，而SPME-MS中的直接解吸每个样品仅消耗极少或不消耗微升有机溶剂，进一步提高了SPME技术的绿色环保性。在过去二十年中，SPME-MS的快速发展催生了众多采用不同电离技术和接口的新技术，其中一些已经商业化。基于今年早些时候发表的一篇广泛综述以及我们的研究经验，我们从这些技术的三个方面提供观点：接口设计与自动化、与先进质谱仪器的整合以及预期的未来发展。
