Chen L H, Thacker R R
Biotechnol Appl Biochem. 1986 Feb;8(1):40-5.
Feeding a basal diet free of vitamins E and C to weanling male rats for 8 months resulted in biochemical changes characteristic of vitamin E deficiency. These included increased liver thiobarbituric acid values; decreased blood GSH levels, plasma vitamin E levels, and glutathione peroxidase activities; and increased activities of plasma pyruvate kinase, glutamic-oxaloacetic transaminase, creatine kinase, lactic dehydrogenase, and malic dehydrogenase. Tube-feeding vitamin C for 21 days resulted in partial reversal effects on the above parameters except activities of glutathione peroxidase, lactic dehydrogenase, and malic dehydrogenase. The results suggest that vitamin C may spare in part the metabolism of vitamin E through its antioxidant property.
给断乳雄性大鼠喂食不含维生素E和C的基础日粮8个月，会导致出现维生素E缺乏的生化变化特征。这些变化包括肝脏硫代巴比妥酸值升高；血液谷胱甘肽（GSH）水平、血浆维生素E水平和谷胱甘肽过氧化物酶活性降低；以及血浆丙酮酸激酶、谷草转氨酶、肌酸激酶、乳酸脱氢酶和苹果酸脱氢酶活性增加。通过管饲法喂食维生素C 21天，除谷胱甘肽过氧化物酶、乳酸脱氢酶和苹果酸脱氢酶活性外，上述参数均出现部分逆转效应。结果表明，维生素C可能通过其抗氧化特性部分节省维生素E的代谢。
