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心血管生物标志物:探索肌钙蛋白和脑钠肽在一氧化碳暴露相关病症中的应用。

Cardiovascular biomarkers: exploring troponin and BNP applications in conditions related to carbon monoxide exposure.

作者信息

Taghdiri Andia

机构信息

Faculty of Medicine, Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia.

出版信息

Egypt Heart J. 2024 Jan 29;76(1):9. doi: 10.1186/s43044-024-00446-w.

Abstract

BACKGROUND

The diagnosis and prognosis of cardiovascular disorders are greatly aided by cardiovascular biomarkers. The uses of troponin and B-type natriuretic peptide in situations involving carbon monoxide exposure are examined in this narrative review. These biomarkers are important because they help predict outcomes in cardiovascular disorders, track the effectiveness of therapy, and influence therapeutic choices.

MAIN BODY

Clinical practice makes considerable use of B-type natriuretic peptide (BNP), which has diuretic and vasodilatory effects, and troponin, a particular marker for myocardial injury. Carbon monoxide (CO) poisoning is a major worldwide health problem because CO, a "silent killer," has significant clinical consequences. Higher risk of cardiac problems, poorer clinical outcomes, and greater severity of carbon monoxide poisoning are all linked to elevated troponin and B-type natriuretic peptide levels. BNP's adaptability in diagnosing cardiac dysfunction and directing decisions for hyperbaric oxygen therapy is complemented by troponin's specificity in identifying CO-induced myocardial damage. When combined, they improve the accuracy of carbon monoxide poisoning diagnoses and offer a thorough understanding of cardiac pathophysiology.

CONCLUSIONS

To sum up, this review emphasizes the importance of troponin and B-type natriuretic peptide (BNP) as cardiac indicators during carbon monoxide exposure. While BNP predicts long-term cardiac problems, troponin is better at short-term morbidity and death prediction. When highly sensitive troponin I (hsTnI) and B-type natriuretic peptide are combined, the diagnostic accuracy of carbon monoxide poisoning patients is improved. One of the difficulties is evaluating biomarker levels since carbon monoxide poisoning symptoms are not always clear-cut. Accurate diagnosis and treatment depend on the investigation of new biomarkers and the use of standardized diagnostic criteria. The results advance the use of cardiovascular biomarkers in the intricate field of carbon monoxide exposure.

摘要

背景

心血管生物标志物对心血管疾病的诊断和预后有很大帮助。本叙述性综述探讨了肌钙蛋白和B型利钠肽在一氧化碳暴露情况下的应用。这些生物标志物很重要,因为它们有助于预测心血管疾病的预后、跟踪治疗效果并影响治疗选择。

主体

临床实践中大量使用具有利尿和血管舒张作用的B型利钠肽(BNP)以及心肌损伤的特定标志物肌钙蛋白。一氧化碳(CO)中毒是一个全球性的主要健康问题,因为CO作为“无声杀手”会产生重大临床后果。肌钙蛋白和B型利钠肽水平升高与心脏问题风险增加、临床结局较差以及一氧化碳中毒的严重程度更高有关。BNP在诊断心脏功能障碍和指导高压氧治疗决策方面的适应性,与肌钙蛋白在识别CO诱导的心肌损伤方面的特异性相辅相成。两者结合使用时,可提高一氧化碳中毒诊断的准确性,并全面了解心脏病理生理学。

结论

总之,本综述强调了肌钙蛋白和B型利钠肽(BNP)作为一氧化碳暴露期间心脏指标的重要性。虽然BNP可预测长期心脏问题,但肌钙蛋白在预测短期发病率和死亡率方面表现更佳。当高敏肌钙蛋白I(hsTnI)和B型利钠肽联合使用时,可提高一氧化碳中毒患者的诊断准确性。其中一个困难是评估生物标志物水平,因为一氧化碳中毒症状并不总是明确的。准确的诊断和治疗依赖于对新生物标志物的研究以及使用标准化诊断标准。这些结果推动了心血管生物标志物在复杂的一氧化碳暴露领域的应用。

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