Jensen J, Riis B J, Strøm V, Christiansen C
Br J Obstet Gynaecol. 1987 Feb;94(2):130-5. doi: 10.1111/j.1471-0528.1987.tb02339.x.
Serum lipids and lipoproteins were examined in 44 healthy postmenopausal women every 3 months during 1 year of treatment with either continuous oestrogen-norethisterone acetate or placebo. Total serum cholesterol and LDL-cholesterol levels were reduced by approximately 15% and 20% (P less than 0.001), respectively in the hormone group but were unchanged in the placebo group. Serum triglycerides levels remained constant in both groups. HDL-cholesterol levels were significantly reduced by approximately 10% in the hormone group but significant reductions of 5-10% also occurred in the placebo group so that differences between the two groups were only significant after 3 months of treatment. Vaginal bleedings were experienced during the first 3 months by eight of the 21 women receiving hormones, but in only one woman after 9 months of therapy. The addition of norethisterone acetate to postmenopausal oestrogen therapy in clinically relevant doses had no adverse effects on lipoproteins as previously reported, even though administered continuously. Moreover, the low frequency of bleeding with continuous oestrogen-progestogen therapy would make this an appropriate alternative in postmenopausal replacement therapy.
在44名健康绝经后女性中，对她们使用连续雌激素 - 醋酸炔诺酮或安慰剂进行为期1年的治疗，每3个月检测一次血清脂质和脂蛋白。激素组的总血清胆固醇和低密度脂蛋白胆固醇水平分别降低了约15%和20%（P < 0.001），而安慰剂组则无变化。两组的血清甘油三酯水平均保持稳定。激素组的高密度脂蛋白胆固醇水平显著降低了约10%，但安慰剂组也有5 - 10%的显著降低，因此两组之间的差异仅在治疗3个月后才显著。接受激素治疗的21名女性中有8名在最初3个月出现阴道出血，但在治疗9个月后只有1名女性出现。如先前报道，在绝经后雌激素治疗中加入临床相关剂量的醋酸炔诺酮，即使持续给药，对脂蛋白也没有不良影响。此外，连续雌激素 - 孕激素治疗引起出血的频率较低，这将使其成为绝经后替代治疗的合适选择。
