Zhang Han, Lin Xiang, Cao Xinyue, Wang Yu, Wang Jinglin, Zhao Yuanjin
Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China.
Bioact Mater. 2023 Nov 26;33:355-376. doi: 10.1016/j.bioactmat.2023.11.012. eCollection 2024 Mar.
Natural polymers are complex organic molecules that occur in the natural environment and have not been subjected to artificial synthesis. They are frequently encountered in various creatures, including mammals, plants, and microbes. The aforementioned polymers are commonly derived from renewable sources, possess a notable level of compatibility with living organisms, and have a limited adverse effect on the environment. As a result, they hold considerable significance in the development of sustainable and environmentally friendly goods. In recent times, there has been notable advancement in the investigation of the potential uses of natural polymers in the field of biomedicine, specifically in relation to natural biomaterials that exhibit antibacterial and antioxidant characteristics. This review provides a comprehensive overview of prevalent natural polymers utilized in the biomedical domain throughout the preceding two decades. In this paper, we present a comprehensive examination of the components and typical methods for the preparation of biomaterials based on natural polymers. Furthermore, we summarize the application of natural polymer materials in each stage of skin wound repair. Finally, we present key findings and insights into the limitations of current natural polymers and elucidate the prospects for their future development in this field.
天然聚合物是存在于自然环境中且未经人工合成的复杂有机分子。它们在包括哺乳动物、植物和微生物在内的各种生物中经常出现。上述聚合物通常来源于可再生资源,与生物体具有显著的相容性,并且对环境的不利影响有限。因此,它们在可持续和环保产品的开发中具有相当重要的意义。近年来,天然聚合物在生物医学领域潜在用途的研究取得了显著进展,特别是在具有抗菌和抗氧化特性的天然生物材料方面。本综述全面概述了过去二十年中生物医学领域常用的天然聚合物。在本文中,我们对基于天然聚合物的生物材料的成分和典型制备方法进行了全面研究。此外,我们总结了天然聚合物材料在皮肤伤口修复各阶段的应用。最后,我们介绍了当前天然聚合物的关键发现和局限性,并阐明了它们在该领域未来发展的前景。