Salmon J F, Carmichael T R, Welsh N H
Br J Ophthalmol. 1987 Mar;71(3):192-6. doi: 10.1136/bjo.71.3.192.
Contrast sensitivity was measured by means of Arden grating plates in 100 patients on medication for pulmonary tuberculosis. The scores were abnormal in 38.2% of the patients whose therapy included ethambutol for three months, and 36.7% of the patients on similar treatment for six months. In comparison with age matched groups of patients on a regimen where streptomycin replaced ethambutol a statistically significant number of the patients on ethambutol had abnormal scores. This study suggests that Arden contrast sensitivity plates would be effective in detecting subclinical toxic optic neuropathy due to ethambutol and therefore could be used for routine monitoring of ocular function of patients on ethambutol. Loss of contrast sensitivity may explain why some patients on ethambutol with normal visual acuity and colour perception may still complain of visual disturbance.
采用 Arden 光栅板对 100 例正在接受肺结核治疗的患者进行对比敏感度测量。在接受含乙胺丁醇治疗三个月的患者中，38.2% 的患者得分异常；在接受类似治疗六个月的患者中，这一比例为 36.7%。与年龄匹配的使用链霉素替代乙胺丁醇治疗方案的患者组相比，使用乙胺丁醇治疗的患者中得分异常的人数具有统计学意义。本研究表明，Arden 对比敏感度板可有效检测乙胺丁醇所致的亚临床中毒性视神经病变，因此可用于对使用乙胺丁醇患者的眼功能进行常规监测。对比敏感度下降可能解释了为什么一些视力和色觉正常的使用乙胺丁醇的患者仍会抱怨视觉障碍。
