Kakisu Y, Adachi-Usami E, Mizota A
Department of Ophthalmology, School of Medicine, Chiba University, Japan.
Doc Ophthalmol. 1987 Dec;67(4):327-34. doi: 10.1007/BF00143950.
Forty-one eyes in 21 cases of ethambutol optic neuropathy were investigated for the pattern visual evoked cortical potential (VECP) and the pattern electroretinogram (ERG). In 21 of the eyes the disappearance VECP responses were not detectable. In the other 20 eyes the peak latency and amplitude of the disappearance VECP were delayed and decreased significantly compared with normal eyes. The recovery of the peak latency of the disappearance VECP in ethambutol optic neuropathy was faster than that of the amplitude. Twelve eyes in six patients were studied by pattern reversal ERG. Though the mean peak latency of the pattern ERG was within normal limits, the mean amplitude was decreased significantly. Our investigations indicated that ethambutol optic neuropathy disturbed not only the optic nerve but also the retina.
对21例乙胺丁醇性视神经病变患者的41只眼进行了图形视觉诱发电位（VECP）和图形视网膜电图（ERG）检查。其中21只眼未检测到VECP反应消失。另外20只眼中，VECP反应消失的峰潜伏期和波幅与正常眼相比明显延迟和降低。乙胺丁醇性视神经病变中VECP反应消失的峰潜伏期恢复比波幅恢复快。对6例患者的12只眼进行了图形翻转ERG检查。虽然图形ERG的平均峰潜伏期在正常范围内，但平均波幅明显降低。我们的研究表明，乙胺丁醇性视神经病变不仅损害视神经，还损害视网膜。
