Kim Miyong T, Murry Nicole, Hecht Jacklyn, Hutson Tara, Nnaka Tonychris, Ewere Tiffany, Heitkemper Elizabeth, Hebert Emily T, Radhakrishnan Kavita, Stuifbergen Alexa
Department of Nursing, University of Texas at Austin School of Nursing, USA.
Department of Health Promotion and Behavioral Sciences, UT Health Houston School of Public Health, USA.
J Neurol Disord. 2022;10(11). Epub 2022 Nov 29.
As the population ages and more people are affected by multiple chronic conditions, the prevalence of Peripheral Neuropathy (PN) has also rapidly increased. This swift rise in PN leaves clinicians and patients challenged by a lack of consistent diagnosis and treatment guidelines.
To assist those affected by PN, it is imperative to understand the breadth of symptoms, experiences, and factors related to the quality of life. The primary aims of this study are to (1) characterize the symptoms of PN in a nationwide sample; (2) discern differences in symptom clusters, given perceived causes of PN; and (3) identify significant physiological symptoms related to the quality of life for people with PN.
An online survey of people in online PN support groups. Participants were recruited primarily an open request sent to recipients of web-based communications from nationally recognized online PN support groups. Inclusion criteria were as follows: Self-reported diagnosis of PN, ability to read English or Spanish, residence in the U.S., and age ≥ 18 years.
A total of 608 individuals with PN were included in the analysis. This sample represents 49 U.S. states and the District of Colombia; 221 were male and 387 female. Their disease severity and etiology were similar to previously reported information on this population, with 53.3% of respondents suffering from PN without a known cause. Among known causes, diabetes was the most common (19.6%), followed by chemotherapy (6.9%) and autoimmune diseases (3.6%). Factors affecting the quality of life among people with PN included lower extremity mobility, upper extremity mobility, sleep disturbance, depressive symptoms, and patient activation.
随着人口老龄化以及越来越多的人受到多种慢性疾病的影响，周围神经病变（PN）的患病率也迅速上升。PN的这种迅速增加使得临床医生和患者面临缺乏一致的诊断和治疗指南的挑战。
为了帮助那些受PN影响的人，必须了解与生活质量相关的症状范围、经历和因素。本研究的主要目的是：（1）在全国范围内的样本中描述PN的症状；（2）鉴于PN的已知病因，辨别症状群的差异；（3）确定与PN患者生活质量相关的重要生理症状。
对在线PN支持小组中的人员进行在线调查。主要通过向全国认可的在线PN支持小组的网络通信收件人发送公开请求来招募参与者。纳入标准如下：自我报告诊断为PN，具备阅读英语或西班牙语的能力，居住在美国，年龄≥18岁。
共有608名PN患者纳入分析。该样本代表美国49个州和哥伦比亚特区；男性221名，女性387名。他们的疾病严重程度和病因与此前关于该人群的报告信息相似，53.3%的受访者患有病因不明的PN。在已知病因中，糖尿病最为常见（19.6%），其次是化疗（6.9%）和自身免疫性疾病（3.6%）。影响PN患者生活质量的因素包括下肢活动能力、上肢活动能力、睡眠障碍、抑郁症状和患者积极性。
