Maget-Dana R, Ptak M, Peypoux F, Michel G
Biochim Biophys Acta. 1987 Mar 26;898(1):1-5. doi: 10.1016/0005-2736(87)90104-0.
A comparison has been made between the pore-forming properties of the antibiotic lipopeptide iturin A and a derivative methylated on the tyrosine residue which shows a restricted biological activity. It is shown that this derivative increases the ion permeability of planar lipid membranes as does iturin A. Nevertheless, the global conductance of the doped membrane is very much lower at the same lipopeptide/phospholipid ratio and the ion selectivity is inverted (PK/PCl = 6 instead of 0.6 with iturin A). The characteristics of the induced conducting pores are also rather different. This suggests an important role of the D-Tyr2 residue, present in all the compounds of the iturin family, both in the biological and in the pore-forming properties of iturin A.
已对抗生素脂肽伊枯草菌素A及其在酪氨酸残基上甲基化的衍生物（其生物活性有限）的成孔特性进行了比较。结果表明，该衍生物与伊枯草菌素A一样能增加平面脂质膜的离子通透性。然而，在相同的脂肽/磷脂比例下，掺杂膜的整体电导率要低得多，并且离子选择性发生了反转（PK/PCl = 6，而伊枯草菌素A为0.6）。诱导形成的导电孔的特性也有很大不同。这表明存在于伊枯草菌素家族所有化合物中的D - Tyr2残基在伊枯草菌素A的生物学特性和成孔特性中都起着重要作用。
