Maget-Dana R, Heitz F, Ptak M, Peypoux F, Guinand M
Biochem Biophys Res Commun. 1985 Jun 28;129(3):965-71. doi: 10.1016/0006-291x(85)91985-0.
Bacterial lipopeptides, known for their antibiotic activities, have been tested for their ability to interact with lipid membranes. These lipopeptides, Iturin A, Bacillomycin L and D and Peptidolipin NA present analogous structural characteristics: a heptapeptidic cycle is linked to a hydrocarbon chain. We present evidence that these lipopeptides modify the conductance of planar bilayers by forming ion-conducting pores.
以其抗菌活性而闻名的细菌脂肽，已针对其与脂质膜相互作用的能力进行了测试。这些脂肽，如伊枯草菌素A、芽孢杆菌霉素L和D以及肽脂NA具有相似的结构特征：一个七肽环与一条烃链相连。我们提供的证据表明，这些脂肽通过形成离子传导孔来改变平面双层膜的电导。
