Maget-Dana R, Ptak M, Peypoux F, Michel G
Biochim Biophys Acta. 1985 May 28;815(3):405-9. doi: 10.1016/0005-2736(85)90367-0.
The addition of iturin A, a lipopeptide antibiotic extracted from Bacillus subtilis, to a bimolecular lipid membrane (BLM) increases dramatically its electrical conductance. For very low concentration of iturin A, discrete conductance steps are observed which are assigned to the formation of conducting pores. The characteristics of these pores depend on the lipid content of the BLM and they change with time. Cholesterol considerably increases the lifetimes of open states. The pores are slightly anion versus cation selective. These first observations unable us to briefly discuss the pore-forming properties of lipopeptides.
将从枯草芽孢杆菌中提取的脂肽抗生素伊枯草菌素A添加到双分子脂质膜（BLM）中，会显著增加其电导率。对于极低浓度的伊枯草菌素A，可观察到离散的电导阶跃，这些阶跃被归因于导电孔的形成。这些孔的特性取决于BLM的脂质含量，并且会随时间变化。胆固醇会显著增加开放状态的寿命。这些孔对阴离子的选择性略高于阳离子。这些初步观察结果使我们能够简要讨论脂肽的成孔特性。
