Klonowski W, Epstein I R
Biophys J. 1987 Feb;51(2):245-8. doi: 10.1016/S0006-3495(87)83329-5.
To treat the kinetics of actin-myosin binding as simply as possible, a one-variable model is developed and the notion of effectivity factors is introduced. An effectivity factor is a ratio of the reaction rate in the presence of cooperativity to that in the noncooperative case and is calculated by averaging cooperativity factors over all sites belonging to one seven-site actin unit. The technique is applicable to a variety of models involving cooperative association and dissociation processes. This averaging assumes the equivalence of all regulated actin units. The model may be solved exactly for arbitrary degrees of "preloading" of subfragment 1 (S1) on the regulated actin.
为了尽可能简化肌动蛋白-肌球蛋白结合动力学的处理，我们建立了一个单变量模型并引入了有效性因子的概念。有效性因子是协同存在时的反应速率与非协同情况下反应速率的比值，通过对属于一个七位点肌动蛋白单元的所有位点的协同因子进行平均来计算。该技术适用于各种涉及协同缔合和解离过程的模型。这种平均假定所有调节性肌动蛋白单元是等效的。对于调节性肌动蛋白上亚片段1（S1）的任意“预加载”程度，该模型都可以精确求解。
