Bateman J R, Pavia D, Sheahan N F, Agnew J E, Clarke S W
Thorax. 1983 Jun;38(6):463-7. doi: 10.1136/thx.38.6.463.
Tracheobronchial mucociliary clearance was measured with the radioaerosol technique in 25 patients with stable, mild asthma, none of whom was taking systemic corticosteroids. The results were compared with those obtained from a control group of 25 healthy subjects matched for age and sex. All patients and healthy subjects were non-smokers. Ventilatory function was significantly impaired in the asthmatic group, which resulted in a more central initial tracheobronchial deposition of inhaled radioaerosol than in the control group. Despite the shorter transit path along the ciliated airways for the tracer radioaerosol in the asthmatic group, mucociliary clearance was found to be significantly poorer than in the healthy control group. This may be important with respect to bronchial mucus plugging.
采用放射性气溶胶技术对25例病情稳定的轻度哮喘患者的气管支气管黏液纤毛清除功能进行了测量，这些患者均未使用全身性皮质类固醇。将结果与25名年龄和性别相匹配的健康对照者组成的对照组所获得的结果进行比较。所有患者和健康受试者均不吸烟。哮喘组的通气功能明显受损，这导致吸入的放射性气溶胶在气管支气管的初始沉积位置比对照组更靠近中心。尽管哮喘组中示踪放射性气溶胶在纤毛气道中的传输路径较短，但发现其黏液纤毛清除功能明显比健康对照组差。这对于支气管黏液堵塞可能具有重要意义。
