Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China.
Academy of Medical Sciences of Zhengzhou University, Zhengzhou, P.R. China.
J Neurosci Res. 2024 Jan;102(1):e25267. doi: 10.1002/jnr.25267.
The central nervous system has long been thought to lack a clearance system similar to the peripheral lymphatic system. Therefore, the clearance of metabolic waste in the central nervous system has been a subject of great interest in neuroscience. Recently, the cerebral lymphatic drainage system, including the parenchymal clearance system and the meningeal lymphatic network, has attracted considerable attention. It has been extensively studied in various neurological disorders. Solute accumulation and neuroinflammation after epilepsy impair the blood-brain barrier, affecting the exchange and clearance between cerebrospinal fluid and interstitial fluid. Restoring their normal function may improve the prognosis of epilepsy. However, few studies have focused on providing a comprehensive overview of the brain clearance system and its significance in epilepsy. Therefore, this review addressed the structural composition, functions, and methods used to assess the cerebral lymphatic system, as well as the neglected association with epilepsy, and provided a theoretical basis for therapeutic approaches in epilepsy.
长期以来，人们一直认为中枢神经系统缺乏类似于外周淋巴系统的清除系统。因此，中枢神经系统内代谢废物的清除一直是神经科学关注的焦点。最近，脑淋巴引流系统，包括实质清除系统和脑膜淋巴网络，引起了广泛关注。在各种神经疾病中，它已经得到了广泛的研究。癫痫后溶质积累和神经炎症会损害血脑屏障，影响脑脊液和细胞间隙之间的交换和清除。恢复其正常功能可能改善癫痫的预后。然而，很少有研究全面概述脑清除系统及其在癫痫中的意义。因此，本综述介绍了脑淋巴系统的结构组成、功能和评估方法，以及与癫痫的被忽视的关联，并为癫痫的治疗方法提供了理论基础。
