Aksel S
Am J Obstet Gynecol. 1979 Sep 1;135(1):96-101.
Plasma concentrations of LHRH were measured by radioimmunoassay in daily samples obtained from 10 normally ovulating women. The normalcy of each menstrual cycle was determined by measuring luteinizing hormone (LH), follicle-stimulating hormone (FSH), total estrogen, and progesterone concentrations. Six women had consistently measurable immunoreactive LH-releasing hormone (LHRH) in every blood sample. In four, LHRH could not be detected in some of the samples, more frequently during the follicular phase. LHRH levels varied between 10 and 35 pg/ml during the menstrual cycle. At midcycle, coincident with the LH surge, the mean LHRH level (17.6 +/- 4.4 pg/ml) was not significantly different from the mean follicular or luteal phase values. The lowest LHRH level, 11.4 +/- 4.6 pg/ml, was observed on the day of the estrogen surge. A detailed evaluation was made of the specific days of the cycle. Blood samples obtained from an indwelling venous catheter every 20 minutes over a 3 or a 5 hour period during the days of the estrogen surge and the LH surge and on the following day showed no correlation between OHRH, LH, and FSH values.
采用放射免疫分析法测定了10名正常排卵女性每日样本中的促性腺激素释放激素（LHRH）血浆浓度。通过测量促黄体生成素（LH）、促卵泡生成素（FSH）、总雌激素和孕酮浓度来确定每个月经周期的正常情况。6名女性的每份血样中均能持续检测到可免疫反应的促黄体生成素释放激素（LHRH）。4名女性的部分样本中无法检测到LHRH，在卵泡期更为常见。月经周期中LHRH水平在10至35 pg/ml之间变化。在月经周期中期，与LH峰同时出现时，LHRH平均水平（17.6 +/- 4.4 pg/ml）与卵泡期或黄体期的平均水平无显著差异。在雌激素峰出现当天观察到最低的LHRH水平，为11.4 +/- 4.6 pg/ml。对月经周期的特定日子进行了详细评估。在雌激素峰和LH峰当天及随后一天，通过留置静脉导管每20分钟采集一次血样，为期3或5小时，结果显示促性腺激素释放激素（OHRH）、LH和FSH值之间无相关性。
