Canola P A, Salles R F de, Daneze E R, Sobreira M F R, Oliveira B E de, Favero M L, Antonioli M L
Department of Veterinary Medicine and Surgery, São Paulo State University (Unesp), School of Agricultural and Veterinarian Sciences, Via de Acesso Prof. Paulo Donato Castellane, Jaboticabal, São Paulo 14884-900, Brazil.
São Paulo State University (Unesp), School of Agricultural and Veterinarian Sciences, Jaboticabal, São Paulo, Brazil.
J Equine Vet Sci. 2024 Mar;134:105010. doi: 10.1016/j.jevs.2024.105010. Epub 2024 Jan 28.
The aim of the study was to compare and correlate levels of ferritin, transferrin, iron and APPs in healthy horses and those surgically treated for strangulating colic. On admission, measurements of inflammatory markers related to iron and total protein, fibrinogen, albumin, haptoglobin and ceruloplasmin were made. The study comprised 22 horses, divided into a control group (CG) of healthy horses (n = 10) and horses with surgically treated acute abdomen (n = 12), obstruction group (OG). The OG was subdivided according to the affected intestinal segment (small vs. large) and according to outcome (survivors vs. non survivors). The OG had higher haptoglobin (34.8±14.2 mg/dL vs 20.8±7.21 mg/dL) and transferrin (487±161 mg/dL vs 369±71.4 mg/dL) values and lower iron (96.9±65 µg/dL vs 218±105 µg/dL) values than the CG. The OG horses with large intestine obstruction had lower values of transferrin (374.6±130 mg/dL) than horses with small intestinal obstruction (598.6±98.9 mg/dL). There was no difference in outcome between horses with large and small intestinal obstruction. Ferritin levels were moderately correlated with total protein (r = 0.594; P = 0.042) and albumin (r = 0.584; P = 0.046) in OG. In the multivariate exploratory analysis, fibrinogen levels were higher in animals that did not survive. In conclusion, haptoglobin, transferrin and iron were useful inflammatory markers for colic in horses. The correlation of ferritin with other APPs shows a possible role of ferritin as an APP in horses. Fibrinogen levels are higher in horses with greater risk of death from strangulating obstructions.
本研究的目的是比较和关联健康马匹以及因绞窄性绞痛接受手术治疗的马匹体内铁蛋白、转铁蛋白、铁和急性时相蛋白（APPs）的水平。入院时，对与铁和总蛋白相关的炎症标志物、纤维蛋白原、白蛋白、触珠蛋白和铜蓝蛋白进行了测量。该研究包括22匹马，分为健康马匹对照组（CG，n = 10）和接受手术治疗的急腹症马匹组（n = 12），即梗阻组（OG）。OG根据受影响的肠段（小肠与大肠）和结局（存活者与非存活者）进行细分。与CG相比，OG的触珠蛋白（34.8±14.2 mg/dL对20.8±7.21 mg/dL）和转铁蛋白（487±161 mg/dL对369±71.4 mg/dL）值更高，而铁（96.9±65 µg/dL对218±105 µg/dL）值更低。大肠梗阻的OG马匹的转铁蛋白值（374.6±130 mg/dL）低于小肠梗阻的马匹（598.6±98.9 mg/dL）。小肠梗阻和大肠梗阻的马匹在结局上没有差异。在OG中，铁蛋白水平与总蛋白（r = 0.594；P = 0.042）和白蛋白（r = 0.584；P = 0.046）呈中度相关。在多变量探索性分析中，未存活动物的纤维蛋白原水平更高。总之，触珠蛋白、转铁蛋白和铁是马匹绞痛有用的炎症标志物。铁蛋白与其他APPs的相关性表明铁蛋白在马匹中可能作为一种APP发挥作用。因绞窄性梗阻死亡风险更高的马匹纤维蛋白原水平更高。
