Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, PR China.
Department of Pharmacy, Zhejiang Cancer Hospital, PR China.
Phytochemistry. 2024 Mar;219:114002. doi: 10.1016/j.phytochem.2024.114002. Epub 2024 Jan 27.
It has been 11 years since ferroptosis, a new mode of programmed cell death, was first proposed. Natural products are an important source of drug discovery. In the past five years, natural product-derived ferroptosis regulators have been discovered in an endless stream. Herein, 178 natural products discovered so far to trigger or resist ferroptosis are classified into 6 structural classes based on skeleton type, and the mechanisms of action that have been reported are elaborated upon. If pharmacodynamic data are sufficient, the structure and bioactivity relationship is also presented. This review will provide medicinal chemists with some effective ferroptosis regulators, which will promote the research of natural product-based treatment of ferroptosis-related diseases in the future.
铁死亡是一种新的细胞程序性死亡方式，自其被首次提出已经过去了 11 年。天然产物是药物发现的重要来源。在过去的五年中，源源不断地发现了源自天然产物的铁死亡调节剂。在此，根据骨架类型将迄今为止发现的 178 种引发或抵抗铁死亡的天然产物分为 6 个结构类别，并详细阐述了已报道的作用机制。如果药效学数据充足，还会呈现结构与生物活性关系。这篇综述将为药物化学家提供一些有效的铁死亡调节剂，这将促进未来基于天然产物治疗铁死亡相关疾病的研究。
