Takizawa Rena, Minamizono Tomoyo, Tsuji Daisuke, Yan Xiao-Jie, Lu Feng-Lai, Yang Xue-Rong, Li Dian-Peng, Akagi Reiko, Kashiwada Yoshiki, Tanaka Naonobu
Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan.
Faculty of Pharmacy, Yasuda Women's University, Hiroshima, 731-0153, Japan.
J Nat Med. 2025 Jan;79(1):196-203. doi: 10.1007/s11418-024-01851-w. Epub 2024 Oct 23.
Phytochemical investigation on the aerial parts of Lysionotus pauciflorus Maxim. (Gesneriaceae), a medicinal plant used in Guangxi Zhuang Autonomous Region, China, resulted in the isolation of 13 secondary metabolites including two methoxyflavones, six flavonoid glycosides, and five caffeoyl phenylethanoid glycosides. Among these, the chemical structures of previously undescribed metabolites (1-3) were elucidated to be nevadensin 7-O-β-D-glucopyranosyl-(1 → 2)-β-D-glucopyranoside (1), nevadensin 7-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranoside (2), and 2-(3,4-dihydroxyphenyl)ethyl-1-O-β-D-apiofuranosyl-(1 → 4)-α-L-rhamnopyranosyl-(1 → 3)-β-D-(6'-O-E-caffeoyl)glucopyranoside (3) by detailed spectroscopic and HPLC analyses. Inhibitory activity of isolated compounds against RSL3-induced ferroptosis on human hepatoma Hep3B cells were evaluated.
对中国广西壮族自治区作为药用植物使用的少花吊石苣苔（苦苣苔科）地上部分进行植物化学研究，从中分离出13种次生代谢产物，包括两种甲氧基黄酮、六种黄酮苷和五种咖啡酰苯乙醇苷。其中，通过详细的光谱分析和高效液相色谱分析，确定了之前未描述的代谢产物（1 - 3）的化学结构，分别为内华达ensin 7 - O - β - D - 吡喃葡萄糖基 - (1 → 2) - β - D - 吡喃葡萄糖苷（1）、内华达ensin 7 - O - β - D - 吡喃葡萄糖基 - (1 → 6) - β - D - 吡喃葡萄糖苷（2）和2 - (3,4 - 二羟基苯基)乙基 - 1 - O - β - D - 阿吡喃糖基 - (1 → 4) - α - L - 鼠李吡喃糖基 - (1 → 3) - β - D - (6'- O - E - 咖啡酰)吡喃葡萄糖苷（3）。评估了分离出的化合物对人肝癌Hep3B细胞中RSL³诱导的铁死亡的抑制活性。
