Su Wanlu, Wang Jie, Chen Kang, Yan Wenhua, Gao Zhengnan, Tang Xulei, Wan Qin, Luo Zuojie, Ning Guang, Mu Yiming
Department of Endocrinology, The First Clinical Medical Center of Chinese People's Liberation Army General Hospital, No. 28 Fuxing Road, Beijing, 100853, China.
School of Medicine, Nankai University, No. 94 Weijin Road, Tianjin, 300071, China.
Diabetol Metab Syndr. 2024 Jan 30;16(1):29. doi: 10.1186/s13098-024-01258-3.
Triglyceride glucose index (TyG index) was related with both type 2 diabetes (T2DM) and hypertension (HTN). Prospective studies linking the TyG index to the incidence of T2DM and HTN comorbidity remain unclear. This study aimed to to explore the longitudinal association between TyG and new-onset T2DM with HTN.
4,434 subjects (1249 males and 3185 females) without initial T2DM and HTN were followed up for 7 years. This study was conducted from November 2011 to August 2018 in the Gucheng, Laoshan and Jinding communities of Beijing. The incidence of T2DM with HTN during the 7-year follow-up was identified as the endpoint. The TyG index was divided into four quartiles: the < 25% level, the 25-50% level, the 50-75% level and the ≥ 75% level. The relationships between the TyG index and T2DM with HTN were evaluated by Cox proportional hazards regression models.
During 7 years, the augmented trend of T2DM with HTN was observed in the participants. After adjusting for all confounding factors, compared with those in the lowest quartile of TyG index, the population in the highest quartile of TyG index had a higher risk of T2DM with HTN (hazard ratio (HR), 2.878; 95% confidence intervals (95% CI), 1.230-6.731, P = 0.015), however, the association remained significant only in the female population (HR 2.753, 95% CI, 1.061-7.139, p = 0.037). The TyG had superior predictive ability of increased risk of T2DM with HTN for the populations of older age (≥ 65 years) (HR 2.694, 95% CI 1.212-5.989, p = 0.015), higher eGFR (≥ 90 mL/(min·1.73 m)) (HR 2.603, 95% CI 1.164-5.818, p = 0.020) or obesity (BMI ≥ 28 kg/m) (HR 2.547, 95% CI 1.001-6.478, p = 0.020).
A population with a higher TyG index level was more likely to have an enhanced incidence of T2DM and HTN comorbidity. TyG index could have the significance of clinical in early protection against T2DM with HTN.
甘油三酯葡萄糖指数（TyG指数）与2型糖尿病（T2DM）和高血压（HTN）均相关。前瞻性研究中关于TyG指数与T2DM和HTN合并症发生率之间的联系仍不明确。本研究旨在探讨TyG与新发T2DM合并HTN之间的纵向关联。
对4434名无初始T2DM和HTN的受试者（1249名男性和3185名女性）进行了7年的随访。本研究于2011年11月至2018年8月在北京古城、崂山和金鼎社区开展。将7年随访期间T2DM合并HTN的发生率确定为终点。TyG指数分为四个四分位数：<25%水平、25 - 50%水平、50 - 75%水平和≥75%水平。通过Cox比例风险回归模型评估TyG指数与T2DM合并HTN之间的关系。
在7年期间，观察到参与者中T2DM合并HTN呈上升趋势。在调整所有混杂因素后，与TyG指数最低四分位数的人群相比，TyG指数最高四分位数的人群发生T2DM合并HTN的风险更高（风险比（HR），2.878；95%置信区间（95%CI），1.230 - 6.731，P = 0.015），然而，这种关联仅在女性人群中仍然显著（HR 2.753，95%CI，1.061 - 7.139，p = 0.037）。TyG对老年（≥65岁）人群（HR 2.694，95%CI 1.212 - 5.989，p = 0.015）、较高估算肾小球滤过率（eGFR）（≥90 mL/(min·1.73 m²)）人群（HR 2.603，95%CI 1.164 - 5.818，p = 0.020）或肥胖（BMI≥28 kg/m²）人群（HR 2.547，95%CI 1.001 - 6.478，p = 0.020）发生T2DM合并HTN风险增加具有更好的预测能力。
TyG指数水平较高的人群更有可能出现T2DM和HTN合并症发生率增加的情况。TyG指数在早期预防T2DM合并HTN方面可能具有临床意义。
