The Department of Health Statistics, School of Public Health, Dalian Medical University, No. 9 South Road, Lvshun District, Dalian City, Liaoning Province, 116044, PR China; Department of Hospital Infection Control, First Affiliated Hospital of Nanchang University, Nanchang University, No. 17 Yong wai zheng street, Nanchang City, Jiangxi Province, 330006, PR China.
The Department of Health Statistics, School of Public Health, Dalian Medical University, No. 9 South Road, Lvshun District, Dalian City, Liaoning Province, 116044, PR China.
Nutr Metab Cardiovasc Dis. 2023 May;33(5):1057-1065. doi: 10.1016/j.numecd.2023.02.014. Epub 2023 Feb 23.
Overweight and obesity are well recognized as important and traditional risk factors for hypertension (HTN), but the prevalence of HTN tends to increase in non-overweight people. Triglyceride-glucose (TyG) index has been observed to be associated with HTN. However, whether such association still persists in non-overweight people remains unclear. The aim of our cohort study was to explore the link between TyG index and incident HTN in non-overweight Chinese population.
As many as 4678 individuals without HTN at baseline were involved, who underwent at least two years of health check-ups in the eight-year study period and maintained non-overweight at follow-up. According to baseline TyG index quintiles, participants were classified into five groups. Compared with the 1st quantile, those in the 5th quantile of TyG index had a 1.73-fold (HR 95% CI 1.13-2.65) risk of incident HTN. The results remained consistent when analyses were restricted to participants without abnormal TG or FPG level at baseline (HR 1.62, 95% CI 1.17-2.26). Furthermore, the subgroup analyses were conducted, the risk of incident HTN was still significantly increased with increasing TyG index for subgroups of older participants (age≥ 40 years), males, females and higher BMI group (BMI≥ 21 kg/m).
The risk of incident HTN increased with increasing TyG index among Chinese non-overweight adults, so TyG index might be a reliable predictor of incident HTN among adults maintaining non-overweight.
超重和肥胖是公认的高血压（HTN）的重要和传统危险因素，但在非超重人群中，HTN 的患病率往往会增加。甘油三酯-葡萄糖（TyG）指数与 HTN 相关。然而，这种关联在非超重人群中是否仍然存在尚不清楚。本队列研究旨在探讨 TyG 指数与中国非超重人群中 HTN 发病的关系。
共有 4678 名基线无 HTN 的个体参与了这项研究，他们在 8 年的研究期间至少进行了两次健康检查，并在随访时保持非超重。根据基线 TyG 指数五分位数，将参与者分为五组。与第 1 分位数相比，TyG 指数第 5 分位数的参与者发生 HTN 的风险增加 1.73 倍（HR 95%CI 1.13-2.65）。当分析仅限于基线 TG 或 FPG 水平正常的参与者时，结果仍然一致（HR 1.62，95%CI 1.17-2.26）。此外，进行了亚组分析，在年龄≥40 岁、男性、女性和 BMI 较高组（BMI≥21kg/m）等亚组中，随着 TyG 指数的增加，发生 HTN 的风险仍然显著增加。
在中国非超重成年人中，随着 TyG 指数的增加，HTN 的发病风险增加，因此 TyG 指数可能是成年人保持非超重时 HTN 发病的可靠预测指标。
