School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Food Funct. 2024 Jul 15;15(14):7252-7270. doi: 10.1039/d3fo04753a.
Ginger ( Roscoe) has traditionally been used as a cooking spice and herbal medicine for treating nausea and vomiting. More recently, ginger was found to effectively reduce the risk of diseases such as gastroenteritis, migraine, gonarthritis, ., due to its various bioactive compounds. 6-Shogaol, the pungent phenolic substance in ginger, is the most pharmacologically active among such compounds. The aim of the present study was to review the pharmacological characteristic of 6-shogaol, including the properties of anti-inflammatory, antioxidant and antitumour, and its corresponding molecular mechanism. With its multiple mechanisms, 6-shogaol is considered a beneficial natural compound, and therefore, this review will shed some light on the therapeutic role of 6-shogaol and provide a theoretical basis for the development and clinical application of 6-shogaol.
姜（Roscoe）自古以来一直被用作烹饪香料和草药，用于治疗恶心和呕吐。最近，由于其具有多种生物活性化合物，姜被发现可有效降低肠胃炎、偏头痛、痛风等疾病的风险。姜辣素是姜中的辛辣酚类物质，是此类化合物中最具药理活性的一种。本研究旨在综述 6-姜辣素的药理特性，包括其抗炎、抗氧化和抗肿瘤特性及其相应的分子机制。由于其多种作用机制，6-姜辣素被认为是一种有益的天然化合物，因此，本综述将阐明 6-姜辣素的治疗作用，并为 6-姜辣素的开发和临床应用提供理论基础。
