Paturle L, Fage D, Fourrier O, Vernier P, Feuerstein C, Demenge P, Scatton B
Brain Res. 1987 Feb 3;402(2):383-6. doi: 10.1016/0006-8993(87)90051-5.
The possible influence of the corticostriatal (glutamatergic) pathway on denervation-induced striatal dopamine target cell supersensitivity has been investigated in the rat by measuring the changes in striatal acetylcholine levels induced by the dopamine agonist pergolide and the basal dopamine D2-receptor density after combined 6-hydroxydopamine-induced lesion of the substantia nigra and cortical ablation. Lesion of the nigrostriatal dopaminergic pathway alone enhanced the ability of pergolide (0.06-1 mg/kg i.p.) to increase acetylcholine levels and increased the maximal density of [3H]spiperone binding sites in the striatum. Similar changes in these biochemical parameters were observed after combined cortical ablation and nigral lesion. Cortical ablation by itself slightly diminished acetylcholine levels and reduced by 30% [3H]spiperone binding site density in the striatum. These results indicate that the corticostriatal tract does not influence striatal dopamine target cell supersensitivity caused by dopaminergic denervation.
通过测量多巴胺激动剂培高利特诱导的纹状体乙酰胆碱水平变化以及在6-羟基多巴胺诱导的黑质损伤和皮层切除联合作用后基底多巴胺D2受体密度，研究了大鼠中皮质纹状体（谷氨酸能）通路对去神经支配诱导的纹状体多巴胺靶细胞超敏反应的可能影响。单独的黑质纹状体多巴胺能通路损伤增强了培高利特（0.06 - 1毫克/千克腹腔注射）增加乙酰胆碱水平的能力，并增加了纹状体中[3H]螺哌隆结合位点的最大密度。在皮层切除和黑质损伤联合作用后，观察到这些生化参数有类似变化。皮层切除本身略微降低了乙酰胆碱水平，并使纹状体中[3H]螺哌隆结合位点密度降低了30%。这些结果表明，皮质纹状体束不影响由多巴胺能去神经支配引起的纹状体多巴胺靶细胞超敏反应。
