Fage D, Guerin B, Feuerstein C, Demenge P, Scatton B
Brain Res. 1984 Sep 24;310(2):379-83. doi: 10.1016/0006-8993(84)90165-3.
Lesion of the nigrostriatal dopaminergic pathway in the rat by 6-hydroxydopamine enhances the ability of pergolide to increase striatal acetylcholine levels and prevents the haloperidol-induced decrease in acetylcholine concentrations. This supersensitive response of striatal cholinergic cells is already maximal 6 days after lesion but tends to decrease thereafter. As the time course of the development of the supersensitivity of cholinergic cells differs from that of increased dopamine binding site density, the two are probably not causally related, the former reflecting rather a change occurring beyond the dopamine recognition site.
6-羟基多巴胺对大鼠黑质纹状体多巴胺能通路的损伤增强了培高利特提高纹状体乙酰胆碱水平的能力，并防止了氟哌啶醇引起的乙酰胆碱浓度降低。纹状体胆碱能细胞的这种超敏反应在损伤后6天已达到最大值，但此后趋于下降。由于胆碱能细胞超敏反应的发展时间进程与多巴胺结合位点密度增加的时间进程不同，两者可能没有因果关系，前者可能反映了多巴胺识别位点之外发生的变化。
