Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, China.
Department of Cardiology, The Second Hospital of Jilin University, Changchun, Jilin, China.
Front Immunol. 2024 Jan 15;14:1341314. doi: 10.3389/fimmu.2023.1341314. eCollection 2023.
As a newly emerging organ transplantation technique, islet transplantation has shown the advantages of minimal trauma and high safety since it was first carried out. The proposal of the Edmonton protocol, which has been widely applied, was a breakthrough in this method. However, direct contact between islets and portal vein blood will cause a robust innate immune response leading to massive apoptosis of the graft, and macrophages play an essential role in the innate immune response. Therefore, therapeutic strategies targeting macrophages in the innate immune response have become a popular research topic in recent years. This paper will summarize and analyze recent research on strategies for regulating innate immunity, primarily focusing on macrophages, in the field of islet transplantation, including drug therapy, optimization of islet preparation process, islet engineering and Mesenchymal stem cells cotransplantation. We also expounded the heterogeneity, plasticity and activation mechanism of macrophages in islet transplantation, providing a theoretical basis for further research.
作为一种新兴的器官移植技术，胰岛移植自首次开展以来，因其创伤小、安全性高而显示出优势。埃德蒙顿方案的提出，广泛应用，这是该方法的一个突破。然而，胰岛与门静脉血的直接接触会引起强烈的固有免疫反应，导致移植物大量凋亡，而巨噬细胞在固有免疫反应中起着至关重要的作用。因此，近年来针对固有免疫反应中巨噬细胞的治疗策略已成为研究热点。本文将对近年来胰岛移植领域中针对固有免疫、主要是巨噬细胞的调节策略进行综述分析，包括药物治疗、胰岛制备过程优化、胰岛工程和间充质干细胞共移植等方面。还阐述了胰岛移植中巨噬细胞的异质性、可塑性和激活机制，为进一步研究提供了理论依据。
