Xie Qiaoqiao, Sun Zhen, Xue Xiu, Pan Yajie, Zhen Shuye, Liu Yang, Zhan Jiuyu, Jiang Linlin, Zhang Jianlong, Zhu Hongwei, Yu Xin, Zhang Xingxiao
School of Life Sciences, Ludong University, Yantai, China.
Collaborative Innovation Center for the Pet Infectious Diseases and Public Health in the Middle and Lower Stream Regions of the Yellow River, Yantai, China.
Front Vet Sci. 2024 Jan 15;11:1328244. doi: 10.3389/fvets.2024.1328244. eCollection 2024.
Feline parvovirus (FPV), a single-stranded DNA virus, is accountable for causing feline panleukopenia, a highly contagious and often lethal disease that primarily affects cats. The epidemiology prevalence and pathogenicity of FPV in certain regions of China, however, remains unclear. The aim of this research was to investigate the epidemiology of FPV in different regions of China in 2021 and compare its infectivity and pathogenicity.
In this research, a total of 36 FPV strains were obtained from diverse regions across China. Phylogenetic analysis was performed based on the VP2 and NS1 sequences, and two representative strains, FPV027 and FPV072, which belonged to different branches, were selected for comparative assessment of infectivity and pathogenicity.
The results revealed that all strains were phylogenetically classified into two groups, G1 and G2, with a higher prevalence of G1 strains in China. Both and experiments demonstrated that FPV072 (G1 group) exhibited enhanced infectivity and pathogenicity compared to FPV027 (G2 Group). The structural alignment of the VP2 protein between the two viruses revealed mutations in residues 91, 232, and 300 that may contribute to differences in infectivity and pathogenicity. The findings from these observations will contribute significantly to the overall understanding of the molecular epidemiology of FPV in China and facilitate the development of an effective FPV vaccine.
猫细小病毒（FPV）是一种单链DNA病毒，可引发猫泛白细胞减少症，这是一种主要影响猫的高度传染性且常具致命性的疾病。然而，FPV在中国某些地区的流行病学流行情况和致病性仍不清楚。本研究的目的是调查2021年中国不同地区FPV的流行病学情况，并比较其传染性和致病性。
在本研究中，共从中国不同地区获得了36株FPV毒株。基于VP2和NS1序列进行系统发育分析，并选择属于不同分支的两株代表性毒株FPV027和FPV072进行传染性和致病性的比较评估。
结果显示，所有毒株在系统发育上分为G1和G2两组，其中G1组毒株在中国的流行率较高。体内和体外实验均表明，与FPV027（G2组）相比，FPV072（G1组）表现出更强的传染性和致病性。两种病毒之间VP2蛋白的结构比对显示，91、232和300位氨基酸残基发生了突变，这可能导致了传染性和致病性的差异。这些观察结果所得出的发现将对全面了解中国FPV的分子流行病学做出重大贡献，并有助于开发有效的FPV疫苗。
