遗传和环境因素对牙齿缺失与口腔潜在恶性疾病和口腔鳞状细胞癌之间关系的影响。

Genetic and environmental contributions for the relationship between tooth loss and oral potentially malignant disorders and oral squamous cell carcinoma.

机构信息

Department of Health, Public Health PhD Program, Universidade Estadual de Feira de Santana, Feira de Santana, Brazil.

Department of Oral and Craniofacial Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

出版信息

Head Neck. 2024 Jun;46(6):1417-1427. doi: 10.1002/hed.27648. Epub 2024 Jan 30.

DOI:10.1002/hed.27648

PMID:38288609

Abstract

BACKGROUND

To investigate the association between tooth loss and oral potentially malignant disorders and oral squamous cell carcinoma, focusing on epidemiological factors and genetic variants.

METHODS

Case-control study, including histologically confirmed oral potentially malignant disorders and oral squamous cell carcinoma cases and healthy controls. Unadjusted and adjusted odds ratios for this association were calculated. Single-nucleotides polymorphisms were tested for individuals with and without missing teeth.

RESULTS

Case individuals were more edentulous while controls had fewer missing teeth (p = 0.006). There was an increased risk for the outcomes associated with edentulism (OR = 6.95, p = 0.000), even after adjustments for educational level (OR = 4.7, p = 0.034) and smoking habits (OR = 5.01, p = 0.022). Among individuals with tooth loss, rs1533767 (WNT11), rs3923087, and rs11867417 (AXIN2) were associated with the outcomes (OR = 1.67, p = 0.03, OR = 0.53, p = 0.05, and OR = 0.42, p = 0.00, respectively).

CONCLUSIONS

Tooth loss could increase the risk for oral potentially malignant disorders and oral squamous cell carcinoma.

摘要

背景

本研究旨在探讨牙齿缺失与口腔潜在恶性疾病和口腔鳞状细胞癌之间的关联，重点关注流行病学因素和遗传变异。

方法

采用病例对照研究，纳入经组织学证实的口腔潜在恶性疾病和口腔鳞状细胞癌病例及健康对照。计算该关联的未经调整和调整后的优势比。对有缺失牙和无缺失牙的个体进行单核苷酸多态性检测。

结果

病例组个体缺牙更多，而对照组个体缺失牙齿较少（p=0.006）。即使在校正了教育水平（OR=4.7，p=0.034）和吸烟习惯（OR=5.01，p=0.022）后，缺牙与结局之间的关联仍具有较高的风险（OR=6.95，p=0.000）。在缺失牙的个体中，rs1533767（WNT11）、rs3923087 和 rs11867417（AXIN2）与结局相关（OR=1.67，p=0.03，OR=0.53，p=0.05，OR=0.42，p=0.00，分别）。