Kristiansson B, Fällström S P
Child Abuse Negl. 1987;11(1):35-40. doi: 10.1016/0145-2134(87)90031-7.
Fifty-five children previously investigated for failure to thrive (a rate of weight gain below -2 SD) during at least 6 weeks at 4-18 months of age were followed up and reinvestigated at the age of 4 years. The children were studied in two groups: children with organic causes (OFTT) (n = 21); and children for whom no organic cause was found (nonorganic failure to thrive, NFTT) (n = 34). In children with OFTT, normalization of growth was found for both weight and height attained, as most of the diseases were either amenable to treatment or spontaneously subsided. The only exception was a child with severe encephalopathy. In children with NFTT, much lower values were found, particularly for weight, p less than .01 for both weight and height. Children with a low psychosocial score (less than or equal to 3 adverse factors) showed partial catch-up growth, although significantly lower than that of children with OFFT. Among 13 children with high psychosocial scores (greater than or equal to 4), 6 children had been subjected to strong social and/or psychological intervention. These children showed a more favorable growth pattern compared to children with comparable psychosocial scores where no intervention had been undertaken. The children with NFTT continued to grow slowly, remained meager and seemed to maintain a suboptimal growth pattern, particularly those with higher numbers of risk factors.
对55名曾因在4至18个月大时体重增长速率低于-2标准差，且至少持续6周存在生长发育迟缓问题而接受过调查的儿童进行了随访，并在他们4岁时再次进行了调查。这些儿童被分为两组：有器质性病因的儿童（器质性生长发育迟缓，OFTT）（n = 21）；以及未发现器质性病因的儿童（非器质性生长发育迟缓，NFTT）（n = 34）。在OFTT儿童中，体重和身高均实现了生长正常化，因为大多数疾病要么可通过治疗改善，要么会自行消退。唯一的例外是一名患有严重脑病的儿童。在NFTT儿童中，各项数值要低得多，尤其是体重，体重和身高的p值均小于0.01。心理社会评分较低（小于或等于3个不利因素）的儿童出现了部分追赶生长，尽管明显低于OFTT儿童。在13名心理社会评分较高（大于或等于4）的儿童中，有6名儿童接受了强烈的社会和/或心理干预。与未进行干预、心理社会评分相当的儿童相比，这些儿童的生长模式更为有利。NFTT儿童继续缓慢生长，体型依然瘦小，似乎维持着不理想的生长模式，尤其是那些风险因素较多的儿童。
