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解析复杂的相互作用:从全面视角理解药物性疾病和致畸性。

Unravelling the Complex Interplay: Understanding Drug-induced Diseases and Teratogenicity from a Comprehensive Perspective.

作者信息

Tiwari Shashank, Prakash Kartikay

机构信息

Department of Pharmacy, Lucknow Model College of Pharmacy, Lucknow, 226008, Uttar Pradesh, India.

Department of Pharmaceutics, Lucknow Model College of Pharmacy, Lucknow, 226008, Uttar Pradesh, India.

出版信息

Curr Drug Res Rev. 2025;17(2):254-265. doi: 10.2174/0125899775283761240118101649.

Abstract

Iatrogenic diseases, also referred to as drug-induced diseases (DIDs), represent a recognized yet inadequately investigated phenomenon that may result in enduring afflictions, hospital admissions, pharmacological interventions, protracted pharmaceutical reliance, and health complications. In the contemporary era of personalized medicine, it is imperative for prescribers to remain abreast of the dynamic advancements in the field of toxicology. Iatrogenic disorders may manifest as a result of medical interventions, including diagnostic procedures, therapeutic interventions, or preventative measures. Key factors to be taken into consideration encompass the patient's chronological age, dietary patterns, genetic predisposition, pre-existing medical conditions, diminished host response mechanisms, and pharmacological tolerance. Teratogenicity pertains to the prevalence of congenital anomalies and disorders resulting from exposure to teratogenic agents, environmental influences, and pharmacological interventions. The primary objective of this review is to provide individuals with comprehensive knowledge regarding the potential risks associated with iatrogenic diseases, thereby facilitating the prevention of unforeseen adverse outcomes.

摘要

医源性疾病,也被称为药物性疾病(DIDs),是一种已被认识但研究尚不充分的现象,可能导致长期痛苦、住院治疗、药物干预、长期药物依赖及健康并发症。在当代个性化医疗时代,开处方者必须紧跟毒理学领域的动态进展。医源性疾病可能因医疗干预而出现,包括诊断程序、治疗干预或预防措施。需要考虑的关键因素包括患者的实际年龄、饮食习惯、遗传易感性、既往病史、宿主反应机制减弱以及药物耐受性。致畸性涉及因接触致畸剂、环境影响和药物干预而导致的先天性异常和疾病的发生率。本综述的主要目的是为个人提供有关医源性疾病潜在风险的全面知识,从而有助于预防意外不良后果。

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