Philpott H L, Nandurkar S, Lubel J, Gibson P R
Department of Gastroenterology, Monash University, Eastern Health, Melbourne, Victoria, Australia.
Box Hill Hospital, Melbourne, Australia.
Frontline Gastroenterol. 2014 Jan;5(1):49-57. doi: 10.1136/flgastro-2013-100316. Epub 2013 Jun 19.
Drug-induced gastrointestinal disorders can mimic conditions, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and, hence, recognition can prevent unnecessary investigations and treatment. While the knowledge and awareness relating to the adverse gastrointestinal effects of some medications, such as non-steroidal anti-inflammatory drugs are well established, other commonly prescribed drugs, such as antipsychotics, antidepressants and metformin are less well understood and warrant further study. This review attempts to integrate recent information regarding adverse drug reactions and place this in a useful clinical context.
药物性胃肠疾病可模拟炎症性肠病(IBD)和肠易激综合征(IBS)等病症,因此,识别这些疾病可避免不必要的检查和治疗。虽然某些药物(如非甾体抗炎药)对胃肠道的不良影响已广为人知,但其他常用药物(如抗精神病药、抗抑郁药和二甲双胍)的相关情况了解较少,值得进一步研究。本综述试图整合有关药物不良反应的最新信息,并将其置于有用的临床背景中。