孕妇就诊于三级医疗中心的产科胆汁淤积症。

Obstetric Cholestasis among Pregnant Women Visiting a Tertiary Care Centre.

机构信息

Department of Obstetrics and Gynaecology, Birat Medical College and Teaching Hospital, Biratnagar, Morang, Nepal.

Department of Paediatrics, Chitwan Medical College, Bharatpur, Chitwan, Nepal.

出版信息

JNMA J Nepal Med Assoc. 2023 Oct 1;61(266):750-754. doi: 10.31729/jnma.8283.

DOI:10.31729/jnma.8283

PMID:38289786

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10579757/

Abstract

INTRODUCTION

Obstetric cholestasis is one of the most frequent hepatic disorders specific to pregnancy. It occurs commonly during the latter half of pregnancy. The data regarding this issue is rare in our settings. The aim of this study was to find out the prevalence of obstetric cholestasis among pregnant women visiting a tertiary care centre.

METHODS

A descriptive cross-sectional study was conducted among pregnant women, who attended a tertiary care centre from 24 July 2022 to 24 January 2023. Ethical approval was taken from the Institutional Review Committee of the same institute. Convenience sampling method was used. The point estimate was calculated at a 99% Confidence Interval.

RESULTS

The prevalence of obstetric cholestasis was 80 (1.38%) (1-1.80, 99% Confidence Interval). A total of 40 (50%) were in the age group 21-30 years, with a mean age of 28.06±6.39 years. A total of 48 (60%) were multigravida and 73 (91.30%) had singleton pregnancies. Pruritus of the whole body was complained of by 56 (70%) patients. Previous history of obstetric cholestasis was present in 21 (26.30%).

CONCLUSIONS

The prevalence of obstetric cholestasis among pregnant women is lower than other studies done in similar settings.

KEYWORDS

Nepal; obstetric cholestasis; pregnancy.

摘要

简介

妊娠肝内胆汁淤积症是妊娠特有的最常见的肝脏疾病之一。它通常发生在妊娠后半期。关于这个问题的数据在我们的环境中很少见。本研究的目的是了解在一家三级保健中心就诊的孕妇中妊娠肝内胆汁淤积症的患病率。

方法

这是一项在 2022 年 7 月 24 日至 2023 年 1 月 24 日期间在一家三级保健中心就诊的孕妇中进行的描述性横断面研究。本研究获得了同一机构的伦理审查委员会的批准。采用方便抽样法。点估计值是在 99%置信区间内计算的。

结果

妊娠肝内胆汁淤积症的患病率为 80 例（1.38%）（1-1.80，99%置信区间）。共有 40 例（50%）年龄在 21-30 岁之间，平均年龄为 28.06±6.39 岁。共有 48 例（60%）为多产妇，73 例（91.30%）为单胎妊娠。56 例（70%）患者抱怨全身瘙痒。21 例（26.30%）有妊娠肝内胆汁淤积症病史。