Department of Internal Medicine, Shree Birendra Hospital, Chhauni, Kathmandu, Nepal.
Department of Biochemistry, Richmond Gabriel University, Arnos Vale, Saint Vincent and the Grenadines.
JNMA J Nepal Med Assoc. 2023 Sep 1;61(265):683-686. doi: 10.31729/jnma.8258.
Transaminitis is a condition where serum aspartate transaminase and alanine transaminase increase indicating liver dysfunction. One such disease where liver involvement might be observed is dengue, which is a mosquito-borne viral infection. The aim of the study was to find out the prevalence of transaminitis among patients with dengue fever in a tertiary care centre.
A descriptive cross-sectional study was conducted in a tertiary care centre from 1 November 2022 to 31 March 2023 after obtaining ethical approval from the Institutional Review Committee. Informed written consent was taken before collecting the data. A rapid immunochromatography test was used to confirm dengue infection. Serum aspartate transaminase and alanine transaminase were measured through routine Reitman and Frankel's enzymatic method. Dengue-confirmed patients from the medical outpatient department, fever clinic, and medical ward of the centre were included in the study. Patients with known prior liver diseases or any other chronic diseases, pregnancy, and patients in the hospice unit were excluded. Convenience sampling method was used. The point estimate was calculated at a 95% Confidence Interval.
Among 442 dengue infected patients, the prevalence of transaminitis was 188 (42.53%) (37.92-47.13, 95% Confidence Interval). The highest frequency of dengue positive was observed among the 18-35 years age group, which was 97 (51.59%) with male predominance 134 (71.27%).
The prevalence of transaminitis among patients with dengue fever in a tertiary care centre was found to be lower than other studies done in similar settings.
alanine transaminase; aspartate transaminase; dengue.
转氨血症是指血清天冬氨酸转氨酶和丙氨酸转氨酶升高，表明肝功能异常。登革热就是一种可能观察到肝脏受累的疾病，它是一种由蚊子传播的病毒感染。本研究旨在探讨三级保健中心登革热患者中转氨酶升高的患病率。
在获得机构审查委员会的伦理批准后，于 2022 年 11 月 1 日至 2023 年 3 月 31 日在一家三级保健中心进行了一项描述性横断面研究。在收集数据之前，获得了知情书面同意。使用快速免疫层析试验来确认登革热感染。通过常规 Reitman 和 Frankel 酶法测量血清天门冬氨酸转氨酶和丙氨酸转氨酶。本研究纳入了来自该中心门诊、发热诊所和内科病房的确诊登革热患者。排除已知有肝脏疾病或任何其他慢性疾病、妊娠和临终关怀病房的患者。采用方便抽样法。点估计值在 95%置信区间内计算。
在 442 例登革热感染患者中，转氨血症的患病率为 188 例（42.53%）（37.92-47.13，95%置信区间）。在 18-35 岁年龄组中观察到登革热阳性的最高频率，为 97 例（51.59%），男性占优势，为 134 例（71.27%）。
在三级保健中心，登革热患者中转氨酶升高的患病率低于在类似环境中进行的其他研究。
丙氨酸转氨酶；天门冬氨酸转氨酶；登革热。
