一种双杂交单克隆抗体靶向肿瘤提高长春花生物碱的治疗效果。
Increased therapeutic effect of vinca alkaloids targeted to tumour by a hybrid-hybrid monoclonal antibody.
作者信息
Corvalan J R, Smith W, Gore V A, Brandon D R, Ryde P J
出版信息
Cancer Immunol Immunother. 1987;24(2):138-43. doi: 10.1007/BF00205591.
Abstract
Unmodified vinblastine (VLB) targeted through one of the antigen combining sites of the hybrid-hybrid 28.19.8 monoclonal is potentially more effective in suppressing the growth of established MAWI tumour xenografts implanted on nude mice than free VLB in the absence of the targeting agent, presumably due to an increased local drug concentration. Our efficacy results in this study suggest that drug, specifically removed from the circulation by hybrid-hybrid antibody previously located to the tumour mass, can be made available in a pharmacologically active from. Histological analysis of the treated tumours revealed dramatic changes in the tumour organisation with only a few surviving tumour cells with altered morphology.
摘要
通过双杂交28.19.8单克隆抗体的一个抗原结合位点靶向的未修饰长春碱（VLB），在抑制植入裸鼠体内的已建立的MAWI肿瘤异种移植物生长方面，可能比没有靶向剂时的游离VLB更有效，这可能是由于局部药物浓度增加。我们在本研究中的疗效结果表明，通过先前定位于肿瘤块的双杂交抗体从循环中特异性去除的药物，可以以药理活性形式提供。对治疗后肿瘤的组织学分析显示肿瘤组织发生了显著变化，只有少数存活的肿瘤细胞形态发生了改变。
相似文献
1
Increased therapeutic effect of vinca alkaloids targeted to tumour by a hybrid-hybrid monoclonal antibody.一种双杂交单克隆抗体靶向肿瘤提高长春花生物碱的治疗效果。
Cancer Immunol Immunother. 1987;24(2):138-43. doi: 10.1007/BF00205591.
2
Specific in vitro and in vivo drug localisation to tumour cells using a hybrid-hybrid monoclonal antibody recognising both carcinoembryonic antigen (CEA) and vinca alkaloids.使用一种既识别癌胚抗原（CEA）又识别长春花生物碱的杂交-杂交单克隆抗体，实现药物在体外和体内对肿瘤细胞的特异性定位。
Cancer Immunol Immunother. 1987;24(2):133-7. doi: 10.1007/BF00205590.
3
Tumour therapy with Vinca alkaloids targeted by a hybrid-hybrid monoclonal antibody recognising both CEA and Vinca alkaloids.
Int J Cancer Suppl. 1988;2:22-5. doi: 10.1002/ijc.2910410708.
4
Suppression of well-established tumour xenografts by a hybrid-hybrid monoclonal antibody and vinblastine.一种杂交-杂交单克隆抗体与长春碱对已建立的肿瘤异种移植瘤的抑制作用。
Cancer Immunol Immunother. 1990;31(3):157-63. doi: 10.1007/BF01744730.
5
Construction and characterisation of a hybrid-hybrid monoclonal antibody recognising both carcinoembryonic antigen (CEA) and vinca alkaloids.一种同时识别癌胚抗原（CEA）和长春花生物碱的杂交-杂交单克隆抗体的构建与表征
Cancer Immunol Immunother. 1987;24(2):127-32. doi: 10.1007/BF00205589.
6
Monoclonal antibodies to antitumor Vinca alkaloids: thermodynamics and kinetics.抗肿瘤长春花生物碱的单克隆抗体：热力学与动力学
Mol Immunol. 1985 Mar;22(3):277-84. doi: 10.1016/0161-5890(85)90162-2.
7
Xenogeneic monoclonal antibodies in the management of cancer: control of their in vivo immunogenicity and induction of specific unresponsiveness using an antibody-drug immunoconjugate.用于癌症治疗的异种单克隆抗体：通过抗体 - 药物免疫偶联物控制其体内免疫原性并诱导特异性无反应性
Br J Cancer. 1991 Aug;64(2):281-7. doi: 10.1038/bjc.1991.292.
8
Site-specific prodrug activation by antibody-beta-lactamase conjugates: preclinical investigation of the efficacy and toxicity of doxorubicin delivered by antibody directed catalysis.抗体-β-内酰胺酶偶联物实现的位点特异性前药激活：通过抗体导向催化递送阿霉素的疗效和毒性的临床前研究
Bioconjug Chem. 1995 Jul-Aug;6(4):440-6. doi: 10.1021/bc00034a014.
9
In vivo antitumor activity of a panel of four monoclonal antibody-vinca alkaloid immunoconjugates which bind to three distinct epitopes of carcinoembryonic antigen.
Bioconjug Chem. 1992 Jul-Aug;3(4):315-22. doi: 10.1021/bc00016a010.
10
The comparative distribution of monoclonal antibodies to CEA in colorectal xenografts.单克隆抗体在结直肠癌异种移植瘤中对癌胚抗原的比较分布。
Tumour Biol. 1984;5(5):255-61.
引用本文的文献
1
Specific in vitro and in vivo drug localisation to tumour cells using a hybrid-hybrid monoclonal antibody recognising both carcinoembryonic antigen (CEA) and vinca alkaloids.使用一种既识别癌胚抗原（CEA）又识别长春花生物碱的杂交-杂交单克隆抗体，实现药物在体外和体内对肿瘤细胞的特异性定位。
Cancer Immunol Immunother. 1987;24(2):133-7. doi: 10.1007/BF00205590.
2
Therapeutic strategies with monoclonal antibodies and immunoconjugates.单克隆抗体和免疫偶联物的治疗策略。
Immunology. 1988 Nov;65(3):329-35.
3
A bispecific monoclonal antibody against methotrexate and a human tumour associated antigen augments cytotoxicity of methotrexate-carrier conjugate.一种针对甲氨蝶呤和一种人类肿瘤相关抗原的双特异性单克隆抗体增强了甲氨蝶呤-载体缀合物的细胞毒性。
Br J Cancer. 1990 Apr;61(4):508-13. doi: 10.1038/bjc.1990.115.
4
Antibody mediated targeting of radioisotopes, drugs and toxins in diagnosis and treatment.抗体介导的放射性同位素、药物和毒素在诊断与治疗中的靶向作用。
Indian J Pediatr. 1990 Jan-Feb;57(1):29-46. doi: 10.1007/BF02722127.
5
Suppression of well-established tumour xenografts by a hybrid-hybrid monoclonal antibody and vinblastine.一种杂交-杂交单克隆抗体与长春碱对已建立的肿瘤异种移植瘤的抑制作用。
Cancer Immunol Immunother. 1990;31(3):157-63. doi: 10.1007/BF01744730.
6
Changes in leucocyte populations following murine bifunctional antibody infusion in colon cancer patients.结肠癌患者输注鼠源双功能抗体后白细胞群体的变化。
Clin Exp Immunol. 1991 May;84(2):289-96. doi: 10.1111/j.1365-2249.1991.tb08163.x.
7
Xenogeneic monoclonal antibodies in the management of cancer: control of their in vivo immunogenicity and induction of specific unresponsiveness using an antibody-drug immunoconjugate.用于癌症治疗的异种单克隆抗体：通过抗体 - 药物免疫偶联物控制其体内免疫原性并诱导特异性无反应性
Br J Cancer. 1991 Aug;64(2):281-7. doi: 10.1038/bjc.1991.292.
8
Therapeutic effect of ansamitocin targeted to tumor by a bispecific monoclonal antibody.双特异性单克隆抗体靶向肿瘤的安丝菌素治疗效果。
Jpn J Cancer Res. 1992 Jul;83(7):761-8. doi: 10.1111/j.1349-7006.1992.tb01977.x.
本文引用的文献
1
Antibody carriers of drugs and toxins in tumor therapy.肿瘤治疗中药物和毒素的抗体载体。
Immunol Rev. 1982;62:1-216.
2
Mouse leukemia: therapy with monoclonal antibodies against a thymus differentiation antigen.小鼠白血病：用抗胸腺分化抗原的单克隆抗体进行治疗。
Science. 1980 Jan 4;207(4426):68-71. doi: 10.1126/science.6965328.
3
A comparison of the content and immunohistochemical patterns of CEA-like activity in human colorectal tumours and nude mouse xenografts.人结肠肿瘤和裸鼠异种移植瘤中癌胚抗原样活性的含量及免疫组化模式比较
Exp Pathol. 1983;24(4):227-35. doi: 10.1016/s0232-1513(83)80010-3.
4
Experimental tumoricidal effects of monoclonal antibody against solid breast tumors.抗实体乳腺肿瘤单克隆抗体的实验性杀瘤效应
Proc Natl Acad Sci U S A. 1983 Dec;80(23):7328-32. doi: 10.1073/pnas.80.23.7328.
5
6
Antitumor properties of vindesine-monoclonal antibody conjugates.长春地辛-单克隆抗体偶联物的抗肿瘤特性。
Cancer Immunol Immunother. 1985;19(1):1-7. doi: 10.1007/BF00199304.
7
Specific in vitro and in vivo drug localisation to tumour cells using a hybrid-hybrid monoclonal antibody recognising both carcinoembryonic antigen (CEA) and vinca alkaloids.使用一种既识别癌胚抗原（CEA）又识别长春花生物碱的杂交-杂交单克隆抗体，实现药物在体外和体内对肿瘤细胞的特异性定位。
Cancer Immunol Immunother. 1987;24(2):133-7. doi: 10.1007/BF00205590.
8
Construction and characterisation of a hybrid-hybrid monoclonal antibody recognising both carcinoembryonic antigen (CEA) and vinca alkaloids.一种同时识别癌胚抗原（CEA）和长春花生物碱的杂交-杂交单克隆抗体的构建与表征
Cancer Immunol Immunother. 1987;24(2):127-32. doi: 10.1007/BF00205589.
9
Studies of methotrexate-monoclonal antibody conjugates for immunotherapy.用于免疫治疗的甲氨蝶呤-单克隆抗体偶联物的研究。
J Natl Cancer Inst. 1985 Aug;75(2):319-32.
10
Drug localisation and growth inhibition studies of vindesine-monoclonal anti-CEA conjugates in a human tumour xenograft.长春地辛-抗癌胚抗原单克隆抗体偶联物在人肿瘤异种移植模型中的药物定位及生长抑制研究
Cancer Immunol Immunother. 1986;21(3):183-7. doi: 10.1007/BF00199359.
Zotero 插件