Capone P M, Papsidero L D, Croghan G A, Chu T M
Proc Natl Acad Sci U S A. 1983 Dec;80(23):7328-32. doi: 10.1073/pnas.80.23.7328.
Two distinct monoclonal antibodies (mAbs) were effective in the therapy of breast carcinomas of human origin established and growing in nude mice. Passive administration of either of the antibodies produced very rapid (less than 1 week) and significant reduction of in vivo tumor volume. Each of the mAbs showed in vivo targeting of the tumors. Histological analysis of mAb-treated tumors revealed extensive cellular necrosis. Each of the antibodies in vitro was effective in complement-mediated cytolysis at a concentration less than 1 ng/ml. The tumoricidal responses show that this is a useful model for passive human immunotherapy using mAbs.
两种不同的单克隆抗体（mAb）对在裸鼠体内建立并生长的人源性乳腺癌具有治疗效果。被动给予这两种抗体中的任何一种，均可使体内肿瘤体积在极短时间内（不到1周）显著缩小。每种单克隆抗体在体内均表现出对肿瘤的靶向性。对经单克隆抗体治疗的肿瘤进行组织学分析，发现存在广泛的细胞坏死。每种抗体在体外浓度低于1 ng/ml时，均可有效介导补体介导的细胞溶解。肿瘤杀伤反应表明，这是一个利用单克隆抗体进行被动人类免疫治疗的有用模型。
