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1
Specific in vitro and in vivo drug localisation to tumour cells using a hybrid-hybrid monoclonal antibody recognising both carcinoembryonic antigen (CEA) and vinca alkaloids.使用一种既识别癌胚抗原（CEA）又识别长春花生物碱的杂交-杂交单克隆抗体，实现药物在体外和体内对肿瘤细胞的特异性定位。
Cancer Immunol Immunother. 1987;24(2):133-7. doi: 10.1007/BF00205590.
2
Tumour therapy with Vinca alkaloids targeted by a hybrid-hybrid monoclonal antibody recognising both CEA and Vinca alkaloids.
Int J Cancer Suppl. 1988;2:22-5. doi: 10.1002/ijc.2910410708.
3
Construction and characterisation of a hybrid-hybrid monoclonal antibody recognising both carcinoembryonic antigen (CEA) and vinca alkaloids.一种同时识别癌胚抗原（CEA）和长春花生物碱的杂交-杂交单克隆抗体的构建与表征
Cancer Immunol Immunother. 1987;24(2):127-32. doi: 10.1007/BF00205589.
4
Increased therapeutic effect of vinca alkaloids targeted to tumour by a hybrid-hybrid monoclonal antibody.一种双杂交单克隆抗体靶向肿瘤提高长春花生物碱的治疗效果。
Cancer Immunol Immunother. 1987;24(2):138-43. doi: 10.1007/BF00205591.
5
Drug localisation and growth inhibition studies of vindesine-monoclonal anti-CEA conjugates in a human tumour xenograft.长春地辛-抗癌胚抗原单克隆抗体偶联物在人肿瘤异种移植模型中的药物定位及生长抑制研究
Cancer Immunol Immunother. 1986;21(3):183-7. doi: 10.1007/BF00199359.
6
Suppression of well-established tumour xenografts by a hybrid-hybrid monoclonal antibody and vinblastine.一种杂交-杂交单克隆抗体与长春碱对已建立的肿瘤异种移植瘤的抑制作用。
Cancer Immunol Immunother. 1990;31(3):157-63. doi: 10.1007/BF01744730.
7
Efficacy and selectivity of vindesine monoclonal anti-carcinoembryonic antigen antibody conjugates on human tumor cell lines grown as xenografts in nude mice.
NCI Monogr. 1987(3):117-24.
8
Targeting of human breast cancer by a bispecific antibody directed against two tumour-associated antigens: ErbB-2 and carcinoembryonic antigen.一种针对两种肿瘤相关抗原（表皮生长因子受体-2和癌胚抗原）的双特异性抗体对人乳腺癌的靶向作用
Tumour Biol. 2002 Nov-Dec;23(6):337-47. doi: 10.1159/000069793.
9
Monoclonal antibodies to antitumor Vinca alkaloids: thermodynamics and kinetics.抗肿瘤长春花生物碱的单克隆抗体：热力学与动力学
Mol Immunol. 1985 Mar;22(3):277-84. doi: 10.1016/0161-5890(85)90162-2.
10
Localisation of monoclonal antibodies reacting with different epitopes on carcinoembryonic antigen (CEA)--implications for targeted therapy.与癌胚抗原（CEA）上不同表位发生反应的单克隆抗体的定位——对靶向治疗的意义
Br J Cancer. 1994 Feb;69(2):307-14. doi: 10.1038/bjc.1994.56.

引用本文的文献

1
Increased therapeutic effect of vinca alkaloids targeted to tumour by a hybrid-hybrid monoclonal antibody.一种双杂交单克隆抗体靶向肿瘤提高长春花生物碱的治疗效果。
Cancer Immunol Immunother. 1987;24(2):138-43. doi: 10.1007/BF00205591.
2
A bispecific monoclonal antibody against methotrexate and a human tumour associated antigen augments cytotoxicity of methotrexate-carrier conjugate.一种针对甲氨蝶呤和一种人类肿瘤相关抗原的双特异性单克隆抗体增强了甲氨蝶呤-载体缀合物的细胞毒性。
Br J Cancer. 1990 Apr;61(4):508-13. doi: 10.1038/bjc.1990.115.
3
The influence of anti-(ricin toxin A chain) monoclonal antibodies on the pharmacokinetics of ricin toxin A chain and recombinant ricin A chain in mice.抗（蓖麻毒素A链）单克隆抗体对蓖麻毒素A链及重组蓖麻毒素A链在小鼠体内药代动力学的影响。
Cancer Immunol Immunother. 1990;32(4):235-40. doi: 10.1007/BF01741706.
4
Antibody mediated targeting of radioisotopes, drugs and toxins in diagnosis and treatment.抗体介导的放射性同位素、药物和毒素在诊断与治疗中的靶向作用。
Indian J Pediatr. 1990 Jan-Feb;57(1):29-46. doi: 10.1007/BF02722127.
5
Suppression of well-established tumour xenografts by a hybrid-hybrid monoclonal antibody and vinblastine.一种杂交-杂交单克隆抗体与长春碱对已建立的肿瘤异种移植瘤的抑制作用。
Cancer Immunol Immunother. 1990;31(3):157-63. doi: 10.1007/BF01744730.
6
Bispecific antibody: a tool for diagnosis and treatment of disease.双特异性抗体：一种用于疾病诊断和治疗的工具。
Clin Exp Immunol. 1990 Mar;79(3):315-21. doi: 10.1111/j.1365-2249.1990.tb08089.x.
7
Changes in leucocyte populations following murine bifunctional antibody infusion in colon cancer patients.结肠癌患者输注鼠源双功能抗体后白细胞群体的变化。
Clin Exp Immunol. 1991 May;84(2):289-96. doi: 10.1111/j.1365-2249.1991.tb08163.x.
8
Xenogeneic monoclonal antibodies in the management of cancer: control of their in vivo immunogenicity and induction of specific unresponsiveness using an antibody-drug immunoconjugate.用于癌症治疗的异种单克隆抗体：通过抗体 - 药物免疫偶联物控制其体内免疫原性并诱导特异性无反应性
Br J Cancer. 1991 Aug;64(2):281-7. doi: 10.1038/bjc.1991.292.
9
Capture of recombinant ricin A chain by a bispecific anti-RTA:anti-CEA monoclonal antibody pre-targeted to a human gastric carcinoma xenograft in nude mice.双特异性抗蓖麻毒素A链：抗癌胚抗原单克隆抗体预先靶向裸鼠人胃癌异种移植瘤对重组蓖麻毒素A链的捕获
J Cancer Res Clin Oncol. 1992;118(5):367-70. doi: 10.1007/BF01294441.
10
Human monocyte-mediated cytotoxicity towards erythrocytes induced by hybrid mouse monoclonal antibodies: effect of antibody binding valency on IgG-Fc gamma R interaction.杂交小鼠单克隆抗体诱导的人单核细胞对红细胞的细胞毒性：抗体结合价对IgG-FcγR相互作用的影响。
Immunology. 1992 Feb;75(2):336-42.

本文引用的文献

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Recombination of a mixture of univalent antibody fragments of different specificity.不同特异性单价抗体片段混合物的重组。
Arch Biochem Biophys. 1961 May;93:460-2. doi: 10.1016/0003-9861(61)90296-x.
2
Hybrid antibodies with dual specificity for the delivery of ricin to immunoglobulin-bearing target cells.具有双重特异性的杂交抗体，用于将蓖麻毒素递送至携带免疫球蛋白的靶细胞。
Cancer Res. 1981 Jun;41(6):2073-8.
3
Immunotoxins: hybrid molecules of monoclonal antibodies and a toxin subunit specifically kill tumour cells.免疫毒素：单克隆抗体与毒素亚基的杂交分子可特异性杀死肿瘤细胞。
Nature. 1981 Mar 12;290(5802):145-6. doi: 10.1038/290145a0.
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In vitro and in vivo efficacy of conjugates of daunomycin with anti-tumor antibodies.柔红霉素与抗肿瘤抗体偶联物的体外和体内疗效
Immunol Rev. 1982;62:5-27. doi: 10.1111/j.1600-065x.1982.tb00387.x.
5
The kinetics of antibody binding to membrane antigens in solution and at the cell surface.抗体与溶液中和细胞表面膜抗原结合的动力学。
Biochem J. 1980 Apr 1;187(1):1-20. doi: 10.1042/bj1870001.
6
Preparation and properties of a drug-carrier-antibody conjugate showing selective antibody-directed cytotoxicity in vitro.一种在体外显示出选择性抗体导向细胞毒性的药物-载体-抗体偶联物的制备及其性质
Int J Cancer. 1983 May 15;31(5):661-70. doi: 10.1002/ijc.2910310520.
7
A comparison of the content and immunohistochemical patterns of CEA-like activity in human colorectal tumours and nude mouse xenografts.人结肠肿瘤和裸鼠异种移植瘤中癌胚抗原样活性的含量及免疫组化模式比较
Exp Pathol. 1983;24(4):227-35. doi: 10.1016/s0232-1513(83)80010-3.
8
Monoclonal antibody and an antibody-toxin conjugate to a cell surface proteoglycan of melanoma cells suppress in vivo tumor growth.单克隆抗体以及与黑色素瘤细胞表面蛋白聚糖结合的抗体-毒素偶联物可抑制体内肿瘤生长。
Proc Natl Acad Sci U S A. 1983 Jan;80(2):529-33. doi: 10.1073/pnas.80.2.529.
9
Immunotoxins: a new approach to cancer therapy.免疫毒素：癌症治疗的新方法。
Science. 1983 Feb 11;219(4585):644-50. doi: 10.1126/science.6218613.
10
Antibody mediated delivery of toxic molecules to antigen bearing target cells.抗体介导的毒性分子向携带抗原的靶细胞的递送。
Immunol Rev. 1982;62:93-117. doi: 10.1111/j.1600-065x.1982.tb00391.x.

使用一种既识别癌胚抗原（CEA）又识别长春花生物碱的杂交-杂交单克隆抗体，实现药物在体外和体内对肿瘤细胞的特异性定位。

Specific in vitro and in vivo drug localisation to tumour cells using a hybrid-hybrid monoclonal antibody recognising both carcinoembryonic antigen (CEA) and vinca alkaloids.

作者信息

Corvalan J R, Smith W, Gore V A, Brandon D R

出版信息

Cancer Immunol Immunother. 1987;24(2):133-7. doi: 10.1007/BF00205590.

DOI:10.1007/BF00205590
PMID:3829047
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11038282/
Abstract

By using a bispecific monoclonal antibody recognising both carcinoembryonic antigen (CEA) and the cytostatic vinca alkaloid drugs we have been able to show specific tumour localisation of vinca alkaloids. In vitro studies with sections of human colorectal tumours have demonstrated that the hybrid-hybrid 28.19.8 monoclonal is able to specifically localise vindesine to cells expressing CEA. Furthermore, the hybrid-hybrid 28.19.8 localises in vivo preferentially to tumour tissues in nude mice bearing the MAWI human xenograft tumour. This tumour-bound hybrid-hybrid monoclonal antibody induces profound changes in the bio-distribution of vinca alkaloid drugs, targeting them specifically to tumour tissues.

摘要

通过使用一种双特异性单克隆抗体，该抗体可识别癌胚抗原（CEA）和细胞生长抑制剂长春花生物碱类药物，我们得以展示长春花生物碱类药物在肿瘤部位的特异性定位。对人结肠肿瘤切片进行的体外研究表明，杂交-杂交单克隆抗体28.19.8能够将长春地辛特异性定位到表达CEA的细胞上。此外，杂交-杂交单克隆抗体28.19.8在体内优先定位于携带MAWI人异种移植肿瘤的裸鼠的肿瘤组织。这种与肿瘤结合的杂交-杂交单克隆抗体可诱导长春花生物碱类药物的生物分布发生显著变化，使其特异性靶向肿瘤组织。