Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Maternal, Fetal & Neonatal Research Center, Family Health Research Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
J Affect Disord. 2024 Apr 15;351:615-623. doi: 10.1016/j.jad.2024.01.238. Epub 2024 Jan 28.
The early years after the onset of psychotic disorders, known as "early psychosis" (EP) are critical to determining the path of psychosis trajectory. We used a Diffusion Magnetic Resonance Imaging (DMRI) connectometry approach to assess the microstructural changes of white matter (WM) associated with EP.
We used the Human Connectome Project in Early Psychosis (HCP-EP) dataset to collect DMRI data from patients with EP. The imaging data were processed in the Montreal Neuroimaging Initiative space and transformed into quantitative anisotropy (QA). The QA value was translated into the WM connectivity of each tract and used in the subsequent analysis.
121 patients with EP (94 non-affective/27 affective) and 56 healthy controls were recruited. EP was associated with increased QA in the body and tapetum of corpus callosum (CC) and decreased QA in the bilateral cerebellum, and middle cerebellar peduncle. Compared to non-affective psychosis, affective psychosis showed increased QA in the bilateral cerebellum and vermis and decreased QA in the forceps minor, body of CC, right cingulum, and bilateral inferior fronto-occipital fasciculus. Furthermore, QA changes in several WM tracts were correlated with positive and negative symptom scale scores.
DMRI intrinsic limitations, limited sample size, and neurobiological effects of psychotropic treatment.
EP is associated with alterations in WM connectivity primarily in the CC and cerebellar regions. Also, affective and non-affective psychosis have distinct alterations in WM connectivity. These results can be used for the early diagnosis and differentiation of psychotic disorders.
精神障碍发病后的早期阶段，即“早期精神病”（EP），对于确定精神病轨迹的发展方向至关重要。我们使用弥散磁共振成像（DMRI）连接测量方法来评估与 EP 相关的白质（WM）的微观结构变化。
我们使用人类连接组计划早期精神病（HCP-EP）数据集从 EP 患者中收集 DMRI 数据。对成像数据进行蒙特利尔神经影像学倡议空间处理，并转换为定量各向异性（QA）。将 QA 值转换为每个束的 WM 连接，并用于后续分析。
共纳入 121 名 EP 患者（94 名非情感性/27 名情感性）和 56 名健康对照者。EP 与胼胝体（CC）体部和压部的 QA 增加以及双侧小脑和小脑中脑脚的 QA 减少有关。与非情感性精神病相比，情感性精神病表现为双侧小脑和蚓部的 QA 增加，以及小内囊脚、胼胝体体部、右侧扣带和双侧下额枕颞束的 QA 减少。此外，几个 WM 束的 QA 变化与阳性和阴性症状量表评分相关。
DMRI 固有局限性、样本量有限以及精神药物治疗的神经生物学效应。
EP 与 WM 连接的改变主要与 CC 和小脑区域有关。此外，情感性和非情感性精神病的 WM 连接存在明显差异。这些结果可用于精神病的早期诊断和鉴别。
