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转基因 Oncopig 癌症模型的优势和机遇。

Benefits and opportunities of the transgenic Oncopig cancer model.

机构信息

Department of Medicine, Division of Hematology & Medical Oncology, University of Missouri, Columbia, MO, USA; Department of Surgery, Section for Thoracic Surgery, University of Missouri, Columbia, MO, USA; Roy Blunt NextGen Precision Health Institute, University of Missouri, Columbia, MO, USA.

National Swine Resource and Research Center, Division of Animal Sciences, University of Missouri, Columbia, MO, USA.

出版信息

Trends Cancer. 2024 Mar;10(3):182-184. doi: 10.1016/j.trecan.2024.01.005. Epub 2024 Jan 29.

DOI:10.1016/j.trecan.2024.01.005
PMID:38290969
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10939816/
Abstract

Cancer remains a leading cause of morbidity and mortality, and a paradigm shift is needed to fundamentally revisit drug development efforts. Pigs share close similarities to humans and may serve as an alternative model. Recently, a transgenic 'Oncopig' line has been generated to induce solid tumors with organ specificity, opening the potential of Oncopigs as a platform for developing novel therapeutic regimens.

摘要

癌症仍然是发病率和死亡率的主要原因，需要进行范式转变，从根本上重新审视药物开发工作。猪与人有密切的相似之处，可能是一种替代模型。最近，生成了一种转基因“Oncopig”系，以诱导具有器官特异性的实体瘤，为开发新的治疗方案提供了 Oncopigs 作为平台的潜力。

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本文引用的文献

[1]
Next batter up! Targeting cancers with KRAS-G12D mutations.

Trends Cancer. 2023-11

[2]
Induction and preliminary characterization of neoplastic pulmonary nodules in a transgenic pig model.

Lung Cancer. 2023-4

[3]
Induction of pancreatic neoplasia in the KRAS/TP53 Oncopig.

Dis Model Mech. 2023-1-1

[4]
Importance of the pig as a human biomedical model.

Sci Transl Med. 2021-11-24

[5]
The Function of the Mutant p53-R175H in Cancer.

Cancers (Basel). 2021-8-13

[6]
Transarterial Embolization of Liver Cancer in a Transgenic Pig Model.

J Vasc Interv Radiol. 2021-4

[7]
Induction and characterization of pancreatic cancer in a transgenic pig model.

PLoS One. 2020-9-21

[8]
An Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants.

Cancer Discov. 2020-11

[9]
Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation.

Oncotarget. 2020-7-14

[10]
MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs.

Nature. 2019-5-8

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