Department of Orthopedics, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, China.
National Clinical Research Center for Geriatric Diseases, Beijing, China.
Eur Spine J. 2024 Mar;33(3):1044-1054. doi: 10.1007/s00586-024-08132-w. Epub 2024 Jan 30.
PURPOSE: This study aimed to develop a predictive model for prolonged length of hospital stay (pLOS) in elderly patients undergoing lumbar fusion surgery, utilizing multivariate logistic regression, single classification and regression tree (hereafter, "classification tree") and random forest machine-learning algorithms. METHODS: This study was a retrospective review of a prospective Geriatric Lumbar Disease Database. The primary outcome measure was pLOS, which was defined as the LOS greater than the 75th percentile. All patients were grouped as pLOS group and non-pLOS. Three models (including logistic regression, single-classification tree and random forest algorithms) for predicting pLOS were developed using training dataset and internal validation using testing dataset. Finally, online tool based on our model was developed to assess its validity in the clinical setting (external validation). RESULTS: The development set included 1025 patients (mean [SD] age, 72.8 [5.6] years; 632 [61.7%] female), and the external validation set included 175 patients (73.2 [5.9] years; 97[55.4%] female). Multivariate logistic analyses revealed that older age (odds ratio [OR] 1.06, p < 0.001), higher BMI (OR 1.08, p = 0.002), number of fused segments (OR 1.41, p < 0.001), longer operative time (OR 1.02, p < 0.001), and diabetes (OR 1.05, p = 0.046) were independent risk factors for pLOS in elderly patients undergoing lumbar fusion surgery. The single-classification tree revealed that operative time ≥ 232 min, delayed ambulation, and BMI ≥ 30 kg/m as particularly influential predictors for pLOS. A random forest model was developed using the remaining 14 variables. Intraoperative EBL, operative time, delayed ambulation, age, number of fused segments, BMI, and RBC count were the most significant variables in the final model. The predictive ability of our three models was comparable, with no significant differences in AUC (0.73 vs. 0.71 vs. 0.70, respectively). The logistic regression model had a higher net benefit for clinical intervention than the other models. The nomogram was developed, and the C-index of external validation for PLOS was 0.69 (95% CI, 0.65-0.76). CONCLUSION: This investigation produced three predictive models for pLOS in elderly patients undergoing lumbar fusion surgery. The predictive ability of our three models was comparable. Logistic regression model had a higher net benefit for clinical intervention than the other models. Our predictive model could inform physicians about elderly patients with a high risk of pLOS after surgery.
目的:本研究旨在利用多元逻辑回归、单分类和回归树(以下简称“分类树”)和随机森林机器学习算法,为接受腰椎融合手术的老年患者开发预测长时间住院(pLOS)的预测模型。 方法:这是一项对前瞻性老年腰椎疾病数据库的回顾性研究。主要结局指标为 pLOS,定义为 LOS 大于第 75 百分位。所有患者均分为 pLOS 组和非 pLOS 组。使用训练数据集开发了三种预测 pLOS 的模型(包括逻辑回归、单分类树和随机森林算法),并使用测试数据集进行内部验证。最后,基于我们的模型开发了在线工具,以评估其在临床环境中的有效性(外部验证)。 结果:开发集包括 1025 名患者(平均[标准差]年龄 72.8[5.6]岁;632[61.7%]女性),外部验证集包括 175 名患者(73.2[5.9]岁;97[55.4%]女性)。多变量逻辑分析显示,年龄较大(比值比[OR]1.06,p<0.001)、BMI 较高(OR 1.08,p=0.002)、融合节段数较多(OR 1.41,p<0.001)、手术时间较长(OR 1.02,p<0.001)和糖尿病(OR 1.05,p=0.046)是老年腰椎融合手术患者 pLOS 的独立危险因素。分类树显示,手术时间≥232 分钟、延迟活动和 BMI≥30kg/m2 是 pLOS 的特别有影响的预测因子。使用其余 14 个变量开发了一个随机森林模型。术中 EBL、手术时间、延迟活动、年龄、融合节段数、BMI 和 RBC 计数是最终模型中最重要的变量。我们三个模型的预测能力相当,AUC 没有显著差异(分别为 0.73、0.71 和 0.70)。逻辑回归模型对临床干预的净效益高于其他模型。开发了列线图,PLOS 的外部验证 C 指数为 0.69(95%CI,0.65-0.76)。 结论:本研究为接受腰椎融合手术的老年患者开发了三种预测 pLOS 的模型。我们三个模型的预测能力相当。逻辑回归模型对临床干预的净效益高于其他模型。我们的预测模型可以为术后有发生 pLOS 高风险的老年患者提供信息。
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