Sports Nutrition Center, National Institute of Sports Medicine, Beijing, 100029, China.
Beijing Sport University, Beijing, 100084, China.
BMC Cardiovasc Disord. 2024 Jan 30;24(1):80. doi: 10.1186/s12872-024-03745-x.
The purpose of this meta-analysis was to evaluate the effect of exercise training intervention in patients with abdominal aortic aneurysm (AAA).
Eight randomized controlled trials (RCTs) that recruited 588 AAA patients were extracted using 4 databases (PubMed, Embase, Wanfang Data, and Cochrane Library). Physiological and biochemistry parameters that included in this study are high-sensitivity C-reactive protein (hs-CRP), respiratory peak oxygen uptake rate (VOpeak), triglyceride (TG), total cholesterol (TC), anaerobic threshold (AT), the diameter of AAA, high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL), and matrix metalloproteinase-9 (MMP-9). Standard mean difference (SMD) was used to assess the between group effect.
This meta-analysis was synthesized with findings from RCTs and found that hs-CRP (SMD, - 0.56 mg/dL; 95% CI: - 0.90 to 0.22; P = 0.001), VOpeak (SMD, 0.4 mL/kg/min; 95% CI, 0.21 to 0.60; P < 0.001), TG (SMD, - 0.39 mg/dL; 95% CI: - 0.02 to 0.77; P = 0.04), and AT (SMD, 0.75 mL/kg/min; 95% CI, 0.54 to 0.96; P < 0.001) were significantly improved in the exercise groups, while the size of AAA (SMD, - 0.15; 95% CI: - 0.36 to 0.06; P = 0.15), TC (SMD, 0.16 mg/dL; 95% CI: - 0.10 to 0.42; P = 0.23), HDL/LDL ratio (SMD, - 0.06; 95% CI: - 0.32 to 0.20; P = 0.64), HDL (SMD, - 0.09; 95% CI: - 0.39 to 0.20; P = 0.54), LDL (SMD, 0.08; 95% CI: - 0.21 to 0.38; P = 0.59), and MMP-9 (SMD, - 0.23 mg/dL; 95% CI: - 0.53 to 0.06; P = 0.12) did not differ in the exercise groups compared with the controls.
Exercise intervention improved some of the CVD risk factors but not all, hs-CRP, VOpeak and AT were significantly improved after exercise intervention, while, changes of MMP-9, the size of AAA, and the overall lipids profile were not. Exercise intervention provides an additional solution for improving cardiorespiratory capacity and health status among AAA patients, and might lead to a delay of AAA progression.
本荟萃分析旨在评估运动训练干预对腹主动脉瘤（AAA）患者的影响。
使用 4 个数据库（PubMed、Embase、万方数据和 Cochrane 图书馆）提取了 588 名 AAA 患者的 8 项随机对照试验（RCT）。本研究包括的生理和生化参数有高敏 C 反应蛋白（hs-CRP）、呼吸峰值摄氧量（VOpeak）、三酰甘油（TG）、总胆固醇（TC）、无氧阈（AT）、AAA 直径、高密度脂蛋白胆固醇（HDL）、低密度脂蛋白胆固醇（LDL）和基质金属蛋白酶-9（MMP-9）。采用标准化均数差（SMD）评估组间效应。
这项荟萃分析综合了 RCT 的研究结果，发现运动组 hs-CRP（SMD，-0.56mg/dL；95%CI：-0.90 至 0.22；P=0.001）、VOpeak（SMD，0.4mL/kg/min；95%CI，0.21 至 0.60；P<0.001）、TG（SMD，-0.39mg/dL；95%CI：-0.02 至 0.77；P=0.04）和 AT（SMD，0.75mL/kg/min；95%CI，0.54 至 0.96；P<0.001）均有显著改善，而 AAA 直径（SMD，-0.15；95%CI：-0.36 至 0.06；P=0.15）、TC（SMD，0.16mg/dL；95%CI：-0.10 至 0.42；P=0.23）、HDL/LDL 比值（SMD，-0.06；95%CI：-0.32 至 0.20；P=0.64）、HDL（SMD，-0.09；95%CI：-0.39 至 0.20；P=0.54）、LDL（SMD，0.08；95%CI：-0.21 至 0.38；P=0.59）和 MMP-9（SMD，-0.23mg/dL；95%CI：-0.53 至 0.06；P=0.12）在运动组与对照组之间没有差异。
运动干预改善了一些 CVD 风险因素，但并非全部。运动干预后，hs-CRP、VOpeak 和 AT 显著改善，而 MMP-9、AAA 直径和整体血脂谱的变化则不明显。运动干预为改善 AAA 患者的心肺能力和健康状况提供了一个额外的解决方案，并可能导致 AAA 进展的延迟。
