desJardins-Park Heather E, Mascharak Shamik, Chinta Malini S, Wan Derrick C, Longaker Michael T
Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Stanford University School of Medicine, Stanford, CA, United States.
Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, United States.
Front Physiol. 2019 Mar 29;10:322. doi: 10.3389/fphys.2019.00322. eCollection 2019.
Fibrosis is intimately linked to wound healing and is one of the largest causes of wound-related morbidity. While scar formation is the normal and inevitable outcome of adult mammalian cutaneous wound healing, scarring varies widely between different anatomical sites. The spectrum of craniofacial wound healing spans a particularly diverse range of outcomes. While most craniofacial wounds heal by scarring, which can be functionally and aesthetically devastating, healing of the oral mucosa represents a rare example of nearly scarless postnatal healing in humans. In this review, we describe the typical wound healing process in both skin and the oral cavity. We present clinical correlates and current therapies and discuss the current state of research into mechanisms of scarless healing, toward the ultimate goal of achieving scarless adult skin healing.
纤维化与伤口愈合密切相关，是伤口相关发病的主要原因之一。虽然瘢痕形成是成年哺乳动物皮肤伤口愈合的正常且不可避免的结果，但不同解剖部位的瘢痕形成差异很大。颅面伤口愈合的结果范围特别多样。虽然大多数颅面伤口通过瘢痕形成愈合，这在功能和美观上可能具有破坏性，但口腔黏膜的愈合是人类出生后几乎无瘢痕愈合的罕见例子。在本综述中，我们描述了皮肤和口腔中的典型伤口愈合过程。我们介绍了临床相关性和当前的治疗方法，并讨论了无瘢痕愈合机制的研究现状，以实现成人皮肤无瘢痕愈合这一最终目标。
