Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Acta Biochim Biophys Sin (Shanghai). 2023 Jul 5;55(9):1337-1347. doi: 10.3724/abbs.2023120.
Ferroptosis, an iron-dependent form of regulated cell death, results in lipid peroxidation of polyunsaturated fatty acids in the cell membrane, which is catalyzed by iron ions and accumulated to lethal levels. It is mechanistically distinct from other forms of cell death, such as apoptosis, pyroptosis, and necroptosis, so it may address the problem of cancer resistance to apoptosis and provide new therapeutic strategies for cancer treatment, which has been intensively studied over the past few years. Notably, considerable advances have been made in the antitumor research of natural products due to their multitargets and few side effects. According to research, natural products can also induce ferroptosis in cancer therapies. In this review we summarize the molecular mechanisms of ferroptosis, introduce the key regulatory genes of ferroptosis, and discuss the progress of natural product research in the field of ferroptosis to provide theoretical guidance for research on natural product-induced ferroptosis in tumors.
铁死亡是一种铁依赖性的细胞程序性死亡方式，其特征是细胞膜中多不饱和脂肪酸发生脂质过氧化，这一过程由铁离子催化并积累到致命水平。它在机制上与其他形式的细胞死亡（如凋亡、细胞焦亡和坏死性凋亡）不同，因此它可能解决了癌细胞对凋亡的抵抗问题，并为癌症治疗提供了新的治疗策略，这在过去几年中得到了深入研究。值得注意的是，由于天然产物具有多靶点和较少的副作用，其在抗肿瘤方面的研究取得了相当大的进展。根据研究，天然产物也可以在癌症治疗中诱导铁死亡。在这篇综述中，我们总结了铁死亡的分子机制，介绍了铁死亡的关键调节基因，并讨论了天然产物在铁死亡领域的研究进展，为肿瘤中天然产物诱导铁死亡的研究提供了理论指导。
